2-benzyl-nonanoic acid amide | 15327-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-benzyl-nonanoic acid amide
• 英文别名: 2-Benzyl-nonansaeure-amid；2-Benzylnonanamide
• CAS: 15327-15-8
• 化学式: C₁₆H₂₅NO
• 分子量: 247.381
• InChiKey: UNDLKBYNIMRTOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 2-benzyl-nonanoic acid amide
  参考文献：
  名称：

  Ketene Acetals. XVII. The Alkylation and Acylation of Substituted Ketene Acetals

  摘要：

  DOI：

  10.1021/ja01214a015

文献信息

• METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES
  申请人：——

  公开号：US20010051184A1

  公开（公告）日：2001-12-13

  The compound curcumin, derived from turmeric, inhibits phosphorylase kinase and, by doing so, exhibits a number of physiological effects related to the control of inflammation and cellular proliferation. However, curcumin is effective only when in solution. Curcumin is almost completely insoluble in water or in oils, but is soluble in alcohols. Accordingly, a method for treating inflammation in a mammal comprising administering curcumin in a solution containing at least one alcohol to a mammal to detectably inhibit the activity of phosphorylase kinase in the blood of the mammal or in a tissue of the mammal. The alcohol is preferably ethanol, 1-propanol, or 2-propanol; most preferably, it is ethanol. Instead of curcumin, a curcumin derivative or curcuminoid can be administered. The method can further comprise the administration of at least one additional compound that can be (1) vitamin D 3 and vitamin D 3 analogues; (2) vitamin A, vitamin A derivatives, and vitamin A analogues (3) a calmodulin inhibitor; (4) an anti-inflammatory drug; (5) a calcium channel blocker; (6) a H1 or H2 histamine blocker; (7) an antioxidant; (8) a polyphenolic compound; (9) a monoterpene; (10) genistein; (11) a soybean derived lectin; and (12) dehydrozingerone. Another aspect of the present invention is a pharmaceutical composition comprising curcumin, a curcuminoid, or a curcumin derivative in a solution containing at least one alcohol, at least one additional compound as described above, and a pharmaceutically acceptable carrier.

  姜黄素是从姜黄中提取的化合物，它能抑制磷酸化酶激酶，并由此产生一系列与控制炎症和细胞增殖有关的生理效应。不过，姜黄素只有在溶液中才有效。姜黄素几乎完全不溶于水或油，但可溶于醇。因此，一种治疗哺乳动物炎症的方法，包括给哺乳动物服用含有至少一种醇的姜黄素溶液，以检测抑制哺乳动物血液或组织中磷酸激酶的活性。醇最好是乙醇、1-丙醇或 2-丙醇；最优选的是乙醇。可以施用姜黄素衍生物或姜黄类化合物来代替姜黄素。该方法可进一步包括施用至少一种额外的化合物，可以是 (1) 维生素 D 3 和维生素 D 3 钙调蛋白抑制剂；(4) 抗炎药物；(5) 钙通道阻滞剂；(6) H1 或 H2 组胺阻滞剂；(7) 抗氧化剂；(8) 多酚化合物；(9) 单萜；(10) 遗传素；(11) 大豆衍生凝集素；(12) 去氢姜酮。本发明的另一方面是一种药物组合物，该组合物包含姜黄素、姜黄类化合物或姜黄素衍生物，其溶液含有至少一种醇、至少一种上述附加化合物和药学上可接受的载体。
• [EN] METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES<br/>[FR] METHODE D'UTILISATION DE CURCUMIN SOLUBLE POUR INHIBER UNE PHOSPHORYLASE KINASE DANS DES MALADIES INFLAMMATOIRES
  申请人：HENG MADALENE C Y

  公开号：WO2000070949A1

  公开（公告）日：2000-11-30

  The compound curcumin, derived from turmeric, inhibits phosphorylase kinase and, by doing so, exhibits a number of physiological effects related to the control of inflammation and cellular proliferation. However, curcumin is effective only when in solution. Curcumin is almost completely insoluble in water or in oils, but is soluble in alcohols. Accordingly, a method for treating inflammation in a mammal comprising administering curcumin in a solution containing at least one alcohol to a mammal to detectably inhibit the activity of phosphorylase kinase in the blood of the mammal or in a tissue of the mammal. The alcohol is preferably ethanol, 1-propanol, or 2-propanol; most preferably, it is ethanol. Instead of curcumin, a curcumin derivative or curcuminoid can be administered. The method can further comprise the administration of at least one additional compound that can be: (1) vitamin D3 and vitamin D3 analogues; (2) vitamin A, vitamin A derivatives, and vitamin A analogues; (3) a calmodulin inhibitor; (4) an anti-inflammatory drug; (5) a calcium channel blocker; (6) a H1 or H2 histamine blocker; (7) an antioxidant; (8) a polyphenolic compound; (9) a monoterpene; (10) genistein; (11) a soybean derived lectin; and (12) dehydrozingerone. Another aspect of the present invention is a pharmaceutical composition comprising curcumin, a curcuminoid, or a curcumin derivative in a solution containing at least one alcohol, at least one additional compound as described above, and a pharmaceutically acceptable carrier.
• Ketene Acetals. XVII. The Alkylation and Acylation of Substituted Ketene Acetals
  作者：S. M. McElvain、R. E. Kent、Calvin L. Stevens

  DOI：10.1021/ja01214a015

  日期：1946.10