9-(2-Hydroxyethyl)hypoxanthin | 22247-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(2-Hydroxyethyl)hypoxanthin
• 英文别名: 9-(2-Hydroxyethyl)-1H-purin-6(9H)-one；9-(2-hydroxyethyl)-1H-purin-6-one
• CAS: 22247-81-0
• 化学式: C₇H₈N₄O₂
• 分子量: 180.166
• InChiKey: ABRQSAMTUHCYEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  次黄嘌呤 、 碳酸乙烯酯 生成 9-(2-Hydroxyethyl)hypoxanthin
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Method of imparting immunomodulating and antiviral activity
  申请人：Newport Pharmaceuticals International, Inc.

  公开号：US04221794A1

  公开（公告）日：1980-09-09

  Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.

  式为##STR1##的化合物，其中X为OH、NH.sub.2、SH、OR或SR（其中R为1至4个碳原子的烷基或苄基），R.sup.1为H或1至8个碳原子的烷基，R.sup.2为H或甲基，Y为式为##STR2##的胺盐，其中R.sup.3和R.sup.4为较低的烷基，例如1至4个碳原子，n为2至4的整数，与对乙酰氨基苯甲酸反应，其中z是从0到10的数字，可用作免疫调节剂、抗病毒剂，在特定情况下具有抗白血病活性。当z为1至10时，该化合物和组合物是新颖的。当R.sup.2为H时，Y的存在增强了免疫调节活性和抗病毒活性。如果X为NH.sub.2，则具有免疫抑制活性，但没有免疫刺激（免疫增强）活性。
• 9-(Hydroxy alkyl)purines
  申请人：Newport Pharmaceuticals International, Inc.

  公开号：US04221910A1

  公开（公告）日：1980-09-09

  There are prepared compounds of the formula ##STR1## where X is OH, R.sup.2 is CH.sub.3 and R.sup.1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.

  有一些化合物的配方已经准备好了，该配方为：##STR1## 其中X为OH，R.sup.2为CH.sub.3，R.sup.1为1至8个碳原子的烷基。这些化合物是免疫增强剂，具有抗病毒活性和抗白血病活性。
• P-Acetamidobenzoic acid salts of 9-(hydroxyalkyl) purines
  申请人：Sloan-Kettering Institute for Cancer Research

  公开号：US04221909A1

  公开（公告）日：1980-09-09

  Compounds of the formula ##STR1## where X is OH, NH.sub.2, SH, OR or SR (where R is alkyl of 1 to 4 carbon atoms or benzyl), R.sup.1 is H or alkyl of 1 to 8 carbon atoms, R.sup.2 is H or methyl, Y is the salt of an amine of the formula ##STR2## where R.sup.3 and R.sup.4 are lower alkyl, e.g., 1 to 4 carbon atoms and n is an integer of 2 to 4 with p-acetamidobenzoic acid and where z is a number from 0 to 10 are useful as immunomodulators, as antiviral agents and in specific cases have anti-leukemic activity. The compounds and compositions where z is 1 to 10 are novel per se. When R.sup.2 is H the presence of Y enhances the immunoregulatory activity and the antiviral activity. If X is the NH.sub.2 there is immunoinhibitory activity but no immunostimulatory (immunopotentiatory) activity.

  式为##STR1##的化合物，其中X为OH、NH.sub.2、SH、OR或SR（其中R为1至4个碳原子的烷基或苄基），R.sup.1为H或1至8个碳原子的烷基，R.sup.2为H或甲基，Y为式为##STR2##的胺盐，其中R.sup.3和R.sup.4为较低的烷基，例如1至4个碳原子，n是2至4的整数，与对乙酰氨基苯甲酸结合，其中z为0至10的数字，可用作免疫调节剂、抗病毒剂，并在特定情况下具有抗白血病活性。其中z为1至10的化合物和组合物本身是新颖的。当R.sup.2为H时，Y的存在增强了免疫调节活性和抗病毒活性。如果X为NH.sub.2，则具有免疫抑制活性但没有免疫刺激（免疫增强）活性。
• Purine compounds endowed with immunomodulating activity
  申请人：CO PHARMA CORPORATION S.r.l.

  公开号：EP0077460A2

  公开（公告）日：1983-04-27

  The invention relates to a series of purine derivatives of formula (I) wherein R is hydrogen or NH2, n is an integer from 1 to 6, R1 is one of the following chains: wherein R2 is the residue of an aminoacid, R3 is hydrogen or the residue of an oligopeptide and R4 is OH or the residue of an oligopeptide.

  本发明涉及一系列式（I）的嘌呤衍生物，其中 R 是氢或 NH2，n 是 1 至 6 的整数，R1 是下列链之一：其中 R2 是氨基酸残基，R3 是氢或低聚肽残基，R4 是 OH 或低聚肽残基。
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