2-(2-氯苄基)-琥珀酸 | 103857-61-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 2-(2-氯苄基)-琥珀酸
• 英文名称: (2-chloro-benzyl)-succinic acid
• 英文别名: (2-Chlor-benzyl)-bernsteinsaeure；2-[(2-Chlorophenyl)methyl]butanedioic acid
• CAS: 103857-61-0
• 化学式: C₁₁H₁₁ClO₄
• 分子量: 242.659
• InChiKey: FTJBLTIWNBZCRC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  马来酸酐 、 2-氯甲苯 在 二叔丁基过氧化物 作用下， 生成 2-(2-氯苄基)-琥珀酸
  参考文献：
  名称：

  Pollen Dispersal in a Hinoki (Chamaecyparis obtusa) Seed Orchard Detected Using a Chloroplast DNA Marker

  摘要：

  DOI：

  10.1007/bf02762716

文献信息

• Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
  申请人：Fogarty Patrick

  公开号：US20080312201A1

  公开（公告）日：2008-12-18

  Methods of using methotrexate (MTX) active agents in which reduced host toxicity is observed are provided. In the subject methods, an effective amount of an MTX active agent is administered to the host in conjunction with the administration of an MTX toxicity reducing agent of the present invention. Also provided are compositions for use in practicing the subject methods, e.g., pharmaceutical compositions having reduced toxicity, in which the MTX active agent is combined with an MTX toxicity reducing agent that reduces the level of undesired MTX toxicity while maintaining an effective MTX anti-proliferative activity. Also provided are methods of using the subject methods and compositions in the treatment of a variety of different disease conditions.
• Pollen Dispersal in a Hinoki (<i>Chamaecyparis obtusa</i>) Seed Orchard Detected Using a Chloroplast DNA Marker
  作者：Kunihiro Seido、Hajime Maeda、Susumu Shiraishi

  DOI：10.1007/bf02762716

  日期：2001.2