Methylene-AzddTTP | 115991-80-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Methylene-AzddTTP
• 英文别名: [(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-[[hydroxy(phosphonooxy)phosphoryl]methyl]phosphinic acid
• CAS: 115991-80-5
• 化学式: C₁₁H₁₈N₅O₁₂P₃
• 分子量: 505.212
• InChiKey: LUYVLMHFQAPSER-DJLDLDEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  224
• 氢给体数：
  5
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  Methylene-AzddTTP 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 水 为溶剂， 20.0 ℃ 、101.32 kPa 条件下， 反应 2.5h， 以74%的产率得到3'-氨基-3'-脱氧胸苷三磷酸酯
  参考文献：
  名称：

  Synthesis of haptens for the development of a solid-phase immobilized epitope-immunoassay (SPIE-IA) of AZT-TP

  摘要：

  The synthesis of the reduced form of AZT-triphosphate, 3'-amino-3'-deoxythymidine-5'-triphosphate, and of its stable analog, 3'-amino-3'-deoxythymidine-5'-(alpha;beta:beta,gamma-bis-methylene)triphosphate, is described. AMT-TP and AMT-PCPCP were prepared to develop a specific immunometric assay for AZT-TP. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)00785-6

文献信息

• Synthesis of haptens for the development of a solid-phase immobilized epitope-immunoassay (SPIE-IA) of AZT-TP
  作者：Luc Lebeau、Thierry Brossette、Laure Goujon、Christophe Créminon、Jacques Grassi、Charles Mioskowski

  DOI：10.1016/s0040-4039(99)00785-6

  日期：1999.6

  The synthesis of the reduced form of AZT-triphosphate, 3'-amino-3'-deoxythymidine-5'-triphosphate, and of its stable analog, 3'-amino-3'-deoxythymidine-5'-(alpha;beta:beta,gamma-bis-methylene)triphosphate, is described. AMT-TP and AMT-PCPCP were prepared to develop a specific immunometric assay for AZT-TP. (C) 1999 Elsevier Science Ltd. All rights reserved.