6-<18F>fluorometaraminol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-<18F>fluorometaraminol
• 英文别名: 3-(2-amino-1-hydroxypropyl)-4-(18F)fluoranylphenol
• 化学式: C₉H₁₂FNO₂
• 分子量: 184.2
• InChiKey: QDBIBBORRNPWOF-LMANFOLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-(acetoxymercurio)-N-t-BOC-metaraminol 生成 6-<18F>fluorometaraminol
  参考文献：
  名称：

  WIELAND, DONALD M.;ROSENSPIRE, KAREN C.;HUTCHINS, GARY D.;VAN, DORT MARCI+, J. MED. CHEM., 33,(1990) N, C. 956-964

  摘要：

  DOI：

文献信息

• 6-[18F]fluorometaraminol. A radiotracer for in vivo mapping of adrenergic nerves of the heart
  作者：Suresh G. Mislankar、David L. Gildersleeve、Donald M. Wieland、Christopher C. Massin、G. Keith Mulholland、Steven A. Toorongian

  DOI：10.1021/jm00397a016

  日期：1988.2

  The false neurotransmitter metaraminol has been 18F labeled and evaluated as a possible heart imaging agent on the basis of its selective accumulation in adrenergic nerves. Reaction of 6-(acetoxymercurio)-N-t-BOC-metaraminol with acetyl hypofluorite followed by removal of the BOC group provides a regiospecific synthesis of 6-fluorometaraminol (4). Use of acetyl hypo[18F]fluorite gives [18F]-4 in 60 min in 20-42% radiochemical yield. Systemic blockade of the neuronal uptake-1 carrier with desmethylimipramine or systemic destruction of the adrenergic nerves with 6-hydroxydopamine lowers [18F]-4 accumulation greater than or equal to 85% in all four regions of the rat heart. These preliminary findings suggest that [18F]-4 could be used to assess neuronal damage in various heart diseases by positron emission tomography.
• MISLANKAR, SURESH G.;GILDERSLEEVE, DAVID L.;WIELAND, DONALD M.;MASSIN, CH+, J. MED. CHEM., 31,(1988) N 2, 362-366
  作者：MISLANKAR, SURESH G.、GILDERSLEEVE, DAVID L.、WIELAND, DONALD M.、MASSIN, CH+

  DOI：——

  日期：——
• WIELAND, DONALD M.;ROSENSPIRE, KAREN C.;HUTCHINS, GARY D.;VAN, DORT MARCI+, J. MED. CHEM., 33,(1990) N, C. 956-964
  作者：WIELAND, DONALD M.、ROSENSPIRE, KAREN C.、HUTCHINS, GARY D.、VAN, DORT MARCI+

  DOI：——

  日期：——