3-氯重氮苯四氟硼酸盐 | 456-39-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 3-氯重氮苯四氟硼酸盐
• 中文别名: 三氯苯四氟硼酸重氮盐；3-氯苯四氟硼酸重氮盐
• 英文名称: 3-Chlorobenzenediazonium tetrafluoroborate
• 英文别名: 3-chlorobenzenediazonium;tetrafluoroborate
• CAS: 456-39-3
• 化学式: C6H4BClF4N2
• 分子量: 226.37
• InChiKey: LCEJXKGRCHEHOK-UHFFFAOYSA-N

物化性质

• 熔点：
  167 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  4.12
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-氯重氮苯四氟硼酸盐 、 三氟甲磺酸 以80%的产率得到
  参考文献：
  名称：

  YONEDA, NORIHIKO;FUKUHARA, TSUYOSHI;MIZOKAMI, TAKAO;SUZUKI, AKIRA, CHEM. LETT.,(1991) N, C. 459-460

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氯苯胺 、 sodium nitrite 、 氟硼酸 生成 3-氯重氮苯四氟硼酸盐
  参考文献：
  名称：

  CITTERIO, A.;FERRARIO, F., J. CHEM. RES. MICROFICHE, 1983, N 12, 308-309

  摘要：

  DOI：

文献信息

• Diamine derivatives
  申请人：Ohta Toshiharu

  公开号：US20050245565A1

  公开（公告）日：2005-11-03

  A compound represented by the general formula (1): Q 1 -Q 2 -T 0 -N(R 1 )-Q 3 -N(R 2 ) -T 1 -Q 4 (1) wherein R 1 and R 2 are hydrogen atoms or the like; Q 1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q 2 is a single bond or the like; Q 3 is a group in which Q 5 is an alkylene group having 1 to 8 carbon atoms, or the like; and T 0 and T 1 are carbonyl groups or the like; a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

  一种化合物，其通式为（1）：Q1-Q2-T0-N（R1）-Q3-N（R2）-T1-Q4（1），其中R1和R2为氢原子或类似物；Q1为饱和或不饱和的5-或6-成员环烃基，可能被取代，或类似物；Q2为单键或类似物；Q3为其中Q5为具有1至8个碳原子的烷基或类似物的基团；T0和T1为羰基基团或类似物；其盐、溶剂化合物或N-氧化物。该化合物可用作预防和/或治疗脑梗死、脑栓塞、心肌梗死、心绞痛、肺梗死、肺栓塞、布尔格病、深静脉血栓形成、弥散性血管内凝血综合征、瓣膜或关节置换后的血栓形成、血管成形术后的血栓形成和再闭塞、全身性炎症反应综合征（SIRS）、多器官功能障碍综合征（MODS）、体外循环期间的血栓形成或采血时的血液凝固。
• DIAMINE DERIVATIVES
  申请人：Ohta Toshiharu

  公开号：US20090270446A1

  公开（公告）日：2009-10-29

  The present invention relates to diamine compounds which inhibit activated blood coagulation factor X and exhibit an anticoagulant effect and there uses for treating various diseases based on thromboembolism.

  本发明涉及抑制激活的血液凝血因子X并具有抗凝作用的二胺化合物及其用于治疗基于血栓栓塞的各种疾病的用途。
• DRUG COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING THROMBOSIS OR EMBOLISM
  申请人：OHTA Toshiharu

  公开号：US20090281074A1

  公开（公告）日：2009-11-12

  Drug compositions containing a substituted diamine compound represented by formula (1): Q 1 -Q 2 -r-N(R 1 )-Q 3 -N(R 2 )  (1) wherein Q 3 represents the following group wherein Q 5 represents an alkylene group having 4 carbon atoms, R 3 represents a hydrogen atom, and R 4 represents a 3-6 membered heterocyclic group which may be substituted; are useful for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

  含有式（1）所代表的取代二胺化合物的药物组合物：Q1-Q2-r-N（R1）-Q3-N（R2）  （1） 其中，Q3代表以下基团 其中，Q5代表具有4个碳原子的烷基基团，R3代表氢原子，R4代表可取代的3-6环杂环基团；用于预防和/或治疗脑梗死、脑栓塞、心肌梗死、心绞痛、肺梗死、肺栓塞、布尔格病、深静脉血栓形成、弥散性血管内凝血综合征、人工瓣膜或关节置换后的血栓形成、血管成形术后的血栓形成和再闭塞、全身性炎症反应综合征（SIRS）、多器官功能障碍综合征（MODS）、体外循环期间的血栓形成或采血时的血液凝固。
• METHOD FOR TREATING THROMBOSIS OR EMBOLISM AND RELATED DISEASES
  申请人：Ohta Toshiharu

  公开号：US20100099660A1

  公开（公告）日：2010-04-22

  A method for treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing is provided. The method includes administration of an effective amount of a compound represented by formula (1):

  提供了一种治疗脑梗死、脑栓塞、心肌梗死、心绞痛、肺梗死、肺栓塞、布尔格病、深静脉血栓形成、弥散性血管内凝血综合征、人工瓣膜或关节置换后的血栓形成、血管成形术后的血栓形成和再闭塞、多器官功能障碍综合征（MODS）、体外循环期间的血栓形成或抽血时的血液凝固的方法。该方法包括给予化合物（1）的有效量：
• Diamine Derivatives
  申请人：Ohta Toshiharu

  公开号：US20110077266A1

  公开（公告）日：2011-03-31

  The present invention relates to diamine compounds which inhibit activated blood coagulation factor X and exhibit an anticoagulant effect and there uses for treating various diseases based on thromboembolism.

  本发明涉及一种抑制活化血液凝血因子X并表现出抗凝效果的二胺化合物和它们在治疗基于血栓栓塞的各种疾病中的应用。