Hydron;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dichloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Hydron;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dichloride
• 化学式: C14H24Cl2N2O3
• mdl: MFCD00243086
• 分子量: 339.3
• InChiKey: VYFLPFGUVGMBEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.91
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  43
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Hydron;1-[(2,3,4-trimethoxyphenyl)methyl]piperazine;dichloride 、 p-Methoxy-phenyl-chloracetat 生成 hydron;(4-methoxyphenyl) 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]acetate;dichloride
  参考文献：
  名称：

  OHTAKA, HIROSHI;YOSHIDA, KENJI;SUKUZI, KENJI;SHIMOHARA, KOICHI;TAJIMA, SI+

  摘要：

  DOI：

文献信息

• N,N+hu 1 +l SUBSTITUTED PIPERAZINES HAVING COMBINED ANTIAGGREGANT, ANTICOAGULANT AND VASODILATORY ACTIVITY, AND METHOD FOR PRODUCING SAME
  申请人：Veselkina Olga Sergejevna

  公开号：US20130267707A1

  公开（公告）日：2013-10-10

  The invention relates to derivatives of N,N′-substituted piperazines of the general formula (I): where R 1 and R 2 denote linear or branched (C 1 -C 4 )alkyl, linear or branched (C 1 -C 4 )alkoxy, CH 3 C(═O)O or halogen; n=1-5; m=0-3; Z denotes CH 2 , C═O or SO 2 ; X denotes C(═NH)NH 2 , C(═NH)NHC(═NH)NH 2 or CH 2 (CHR 3 ) p CH 2 SO 3 H, where R 3 denotes H, OH, CH 3 C(═O)O or HOSO 2 O and p=0-1; and G denotes low-molecular-weight organic or mineral acid, sodium, potassium or ammonium cations, or water. Said derivatives have antiaggregant, anticoagulant and vasodilatory properties. The invention further relates to a method for producing said derivatives by reacting N-substituted piperazines either with carboxamide amidating agents or salts thereof, or with haloalkyl sulfonic acids or salts thereof in organic solvents or in water in the presence of bases. The compounds may be used for the prophylaxis and treatment of disorders of the hemostatic system.

  该发明涉及一般式（I）的N,N′-取代哌嗪衍生物，其中R1和R2表示线性或支链（C1-C4）烷基，线性或支链（C1-C4）烷氧基，CH3C(═O)O或卤素；n=1-5；m=0-3；Z表示CH2，C═O或SO2；X表示C(═NH)NH2，C(═NH)NHC(═NH)NH2或CH2(CHR3)pCH2SO3H，其中R3表示H，OH，CH3C(═O)O或HOSO2O，p=0-1；G表示低分子量有机或矿物酸，钠，钾或铵阳离子，或水。所述衍生物具有抗凝、抗凝血和扩血管作用。该发明还涉及一种通过将N-取代哌嗪与羧酰胺化剂或其盐，或卤代烷磺酸或其盐在有机溶剂或水中在碱的存在下反应而制备所述衍生物的方法。这些化合物可用于预防和治疗止血系统疾病。
• Pharmaceutical combination of betahistine and trimetazidine
  申请人：Deva Holding Anonim Sirketi

  公开号：EP2491930A1

  公开（公告）日：2012-08-29

  This invention is related to pharmaceutical combination of betahistine or pharmaceutically acceptable salts thereof and trimetazidine or pharmaceutically acceptable salts thereof.

  这项发明涉及贝他组胺或其药用可接受盐和三甲嗪或其药用可接受盐的药物组合。
• 1-(2,3,4-tri-methoxybenzyl)-4[bis(4-fluorophenyl)methyl] piperazines are
  申请人：Kanebo Ltd.

  公开号：US04663325A1

  公开（公告）日：1987-05-05

  A 1-benzyl-4-benzhydrylpiperazine derivative represented by the following general formula (I) ##STR1## wherein R.sup.1 represents a hydrogen atom or a methoxy group, and R.sup.2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The 1-benzyl-4-benzhydrylpiperazine derivative or an acid addition salt thereof is prepared by reductively condensing a benzaldehyde derivative with a fluorobenzhydrylpiperazine, or condensing a benzyl halide derivative with a fluorobenzhydrylpiperazine optionally in the presence of an acid acceptor, or condensing a benzylpiperazine with a fluorobenzhydryl halide derivative and, optionally converting the product to its acid addition salt. The 1-benzyl-4-benzhydrylpiperazine derivative is useful for improving a cerebrovascular disease.

  以下是翻译结果： 一种由以下一般式（I）表示的1-苄基-4-苄基二苯基哌嗪衍生物 ##STR1## 其中R1代表氢原子或甲氧基，R2代表氢原子或氟原子，或其药学上可接受的酸加成盐。该1-苄基-4-苄基二苯基哌嗪衍生物或其酸加成盐可以通过还原缩合苯甲醛衍生物和氟苄基二苯基哌嗪，或在酸受体的存在下缩合苄基卤代物和氟苄基二苯基哌嗪，或缩合苄基哌嗪和氟苄基卤代物，并可选择将产物转化为其酸加成盐来制备。该1-苄基-4-苄基二苯基哌嗪衍生物可用于改善脑血管疾病。
• Piperazine compounds and anti-ulcer composition containing the same
  申请人：Kanebo, Ltd.

  公开号：US04797400A1

  公开（公告）日：1989-01-10

  Novel piperazine compounds of the formula: ##STR1## wherein either one of R.sup.1 and R.sup.2 is methoxy group and another is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof, which have excellent anti-peptic ulcer activities with potent activity for promoting the action of the defensive factor, and hence are useful as an anti-ulcer agent for the prophylaxis and treatment of peptic ulcers.

  该专利涉及一种新型哌嗪化合物，其化学式为：##STR1## 其中R.sup.1和R.sup.2中有一个为甲氧基基团，另一个为氢原子，或其药学上可接受的酸盐，该化合物具有出色的抗消化性溃疡活性，对促进防御因子的作用具有强效活性，因此可用作预防和治疗消化性溃疡的抗溃疡剂。
• Novel piperazine derivatives, processes for production thereof, and pharmaceutical compositions comprising said compounds as active ingredient
  申请人：KANEBO, LTD.

  公开号：EP0159566A1

  公开（公告）日：1985-10-30

  A 1-benzyl-4-benzhydrylpiperazine derivative represented by the following general formula (I) wherein R1 represents a hydrogen atom or a methoxy group, and R2 represents a hydrogen or fluorine atom, or a pharmaceutically acceptable acid addition salt thereof. The 1-benzyl-4-benzhydrylpiperazine derivative or an acid addition salt thereof is prepared by reductively condensing a benzaldehyde derivative with a fluorobenzhydrylpiperazine, or condensing a benzyl halide derivative with a fluorobenzhydrylpiperazine optionally in the presence of an acid acceptor, or condensing a benzylpiperazine with a fluorobenzhydryl halide derivative and, optionally converting the product to its acid addition salt. The 1-benzyl-4-benzhydrylpiperazine derivative is useful for improving a cerebrovascular disease.

  由以下通式（I）代表的 1-苄基-4-二氢哌嗪衍生物 其中 R1 代表氢原子或甲氧基，R2 代表氢原子或氟原子，或其药学上可接受的酸加成盐。 1-苄基-4-苯二甲酰基哌嗪衍生物或其酸加成盐的制备方法为：将苯甲醛衍生物与氟苯二甲酰基哌嗪还原缩合，或将苄基卤化物衍生物与氟苯二甲酰基哌嗪缩合（可选择在有酸接受体存在的情况下），或将苄基哌嗪与氟苯二甲酰基卤化物衍生物缩合，并可选择将产物转化为其酸加成盐。 1-苄基-4-二苯甲基哌嗪衍生物可用于改善脑血管疾病。

表征谱图