4,6-dimethyl-3-[3-(4-nitrophenyl)prop-2-enoyl]-1H-pyridin-2-one | 354146-71-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,6-dimethyl-3-[3-(4-nitrophenyl)prop-2-enoyl]-1H-pyridin-2-one
• CAS: 354146-71-7
• 化学式: C₁₆H₁₄N₂O₄
• 分子量: 298.298
• InChiKey: NBMGCWVRARSKME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  92
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-乙酰基-4,6-二甲基-2(1H)-吡啶酮 、 对硝基苯甲醛 在 potassium hydroxide 作用下， 以 水 为溶剂， 反应 16.0h， 以58%的产率得到4,6-dimethyl-3-[3-(4-nitrophenyl)prop-2-enoyl]-1H-pyridin-2-one
  参考文献：
  名称：

  Features of reaction of aromatic nitro-substituted aldehydes with ketones on the matrix of 2(1H)-pyridone

  摘要：

  Condensation of nitrobenzaldehydes with 3-acetyl-4,6-dimethyl-2(1H)-pyridone gives rise to chalcones with high yield. Condensation of the close analogs of 3-acetyl-4,6-dimethyl-2(1H)-pyridone containing ethyl and benzyl radical was established to give stable products of aldol condensation, the corresponding alcohols, under the same conditions.

  DOI：

  10.1134/s1070363209060292

文献信息

• Features of reaction of aromatic nitro-substituted aldehydes with ketones on the matrix of 2(1H)-pyridone
  作者：V. V. Kalashnikov、I. P. Kalashnikova

  DOI：10.1134/s1070363209060292

  日期：2009.6

  Condensation of nitrobenzaldehydes with 3-acetyl-4,6-dimethyl-2(1H)-pyridone gives rise to chalcones with high yield. Condensation of the close analogs of 3-acetyl-4,6-dimethyl-2(1H)-pyridone containing ethyl and benzyl radical was established to give stable products of aldol condensation, the corresponding alcohols, under the same conditions.