2-(fluoromethoxy)-1,1'-biphenyl | 1551327-97-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(fluoromethoxy)-1,1'-biphenyl
• 英文别名: 1-(Fluoromethoxy)-2-phenylbenzene
• CAS: 1551327-97-9
• 化学式: C₁₃H₁₁FO
• 分子量: 202.228
• InChiKey: XVLYNHXQUFLKIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (联苯-2-氧基)-乙酸 在 tris(bipyridine)ruthenium(II) dichloride hexahydrate 、 Selectfluor 、 sodium hydroxide 作用下， 以 水 、 乙腈 为溶剂， 反应 1.0h， 以89%的产率得到2-(fluoromethoxy)-1,1'-biphenyl
  参考文献：
  名称：

  Direct C–F Bond Formation Using Photoredox Catalysis

  摘要：

  We have developed the first example of a photoredox catalytic method for the formation of carbon-fluorine (C-F) bonds. The mechanism has been studied using transient absorption spectroscopy and involves a key single-electron transfer from the (MLCT)-M-3 (triplet metal-to-ligand charge transfer) state of Ru(bpy)(3)(2+) to Selectfluor. Not only does this represent a new reaction for photoredox catalysis, but the mild reaction conditions and use of visible light also make it a practical improvement over previously developed UV-mediated decarboxylative fluorinations.

  DOI：

  10.1021/ja412083f

文献信息

• SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1244617A1

  公开（公告）日：2002-10-02
• [EN] SUBSTITUTED AMINOALKYLAMIDE DERIVATIVES AS ANTAGONISTS OF FOLLICLE STIMULATING HORMONE<br/>[FR] DERIVES D'AMINOALKYLAMIDE SUBSTITUES UTILISES EN TANT QU'ANTAGONISTES DE L'HORMONE FOLLICULOSTIMULANTE
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2001047875A1

  公开（公告）日：2001-07-05

  The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.