4-methyl-2,6-bis((pyridin-2-ylmethylamino)methyl)phenol | 1009318-34-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-2,6-bis((pyridin-2-ylmethylamino)methyl)phenol
• 英文别名: 4-Methyl-2,6-bis[(pyridin-2-ylmethylamino)methyl]phenol
• CAS: 1009318-34-6
• 化学式: C₂₁H₂₄N₄O
• 分子量: 348.448
• InChiKey: NHASAUZRYGRQNC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  70.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[[4-(Chloromethyl)-3-hydroxyphenyl]methyl]isoindole-1,3-dione 、 4-methyl-2,6-bis((pyridin-2-ylmethylamino)methyl)phenol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以33%的产率得到2-[[4-[[[3-[[[4-[(1,3-Dioxoisoindol-2-yl)methyl]-2-hydroxyphenyl]methyl-(pyridin-2-ylmethyl)amino]methyl]-2-hydroxy-5-methylphenyl]methyl-(pyridin-2-ylmethyl)amino]methyl]-3-hydroxyphenyl]methyl]isoindole-1,3-dione
  参考文献：
  名称：

  Ammonium-Bearing Dinuclear Copper(II) Complex: A Highly Selective and Sensitive Colorimetric Probe for Pyrophosphate

  摘要：

  Two dinuclear copper complexes with and without ammonium moieties were synthesized. The complexes exhibited selective binding affinity to pyrophosphate in aqueous solution. The dinuclear copper complex, with ammonium arms, showed a ca. 527-fold enhancement in pyrophosphate binding affinity compared with its analogue without ammonium units.

  DOI：

  10.1021/ol5007339
• 作为产物：
  描述：

  2,6-二甲酰-4-甲基苯酚 在 sodium tetrahydroborate 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 生成 4-methyl-2,6-bis((pyridin-2-ylmethylamino)methyl)phenol
  参考文献：
  名称：

  Schindler, Siegfried; Elias, Horst; Paulus, Helmut, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1990, vol. 45, # 5, p. 607 - 618

  摘要：

  DOI：

文献信息

• Efficient enhancement of DNA cleavage activity by introducing guanidinium groups into diiron(III) complex
  作者：Xiaoqiang Chen、Jingyun Wang、Shiguo Sun、Jiangli Fan、Song Wu、Jianfeng Liu、Saijian Ma、Lizhu Zhang、Xiaojun Peng

  DOI：10.1016/j.bmcl.2007.11.001

  日期：2008.1

  binuclear iron(III) systems. Compared with the corresponding analogue without guanidinium groups, the new diiron(III) system led to considerable rate enhancement on DNA cleavage. The cooperativity between metal ions and guanidine groups was evidenced by the fact that no significant cleavage was observed after incubating pBR322 plasmid DNA with non-metalated ligands or free Fe3+ ion. DNA binding experiments

  受天然核酸酶结构的启发，将胍基引入双核铁（III）系统。与没有胍基的相应类似物相比，新的二价铁（III）系统显着提高了DNA切割的速率。通过将pBR322质粒DNA与非金属化的配体或游离的Fe3 +离子孵育后，未观察到明显的裂解这一事实证明了金属离子与胍基之间的协同作用。DNA结合实验表明，引入带正电荷的胍基可以使复合物与DNA的亲和力提高一个数量级以上。
• RESIN COMPOSITION AND PROCESS FOR PRODUCING THE SAME
  申请人：Japan as represented by Secretary of Agency of Industrial Science and Technology

  公开号：EP1114836A1

  公开（公告）日：2001-07-11

  A curable resin composition, which comprises a resin formed, in the presence of a transition metal complex, by polymerizing an oxidative-polymerizable compound that contains a phenol-compound-containing vegetable oil. A method for producing a curable resin composition comprising a resin formed, in the presence of a catalyst, by polymerizing an oxidative-polymerizable compound that contains a phenol-compound-containing vegetable oil, wherein the catalyst is a transition metal complex. The curable resin composition is useful as a raw material for a urushi-like coating, a friction material, a brake lining material, a brake pad material, a material for forming a coating film, a compound for a recording material, a raw material for an ink, a raw material for a coating, a raw material for a adhesive, a raw material for an epoxy resin, a raw material for a photoresist or antioxidant, and a starting material for a functional polymer.

  一种可固化树脂组合物，它包括在过渡金属络合物存在下，通过聚合含有含酚化合物的植物油的可氧化聚合化合物而形成的树脂。一种生产可固化树脂组合物的方法，该树脂组合物包括在催化剂存在下，通过聚合含有含酚化合物植物油的可氧化聚合化合物而形成的树脂，其中催化剂为过渡金属络合物。这种可固化树脂组合物可用作乌拉石般的涂层的原料、摩擦材料、制动衬片材料、制动片材料、形成涂膜的材料、记录材料的化合物、油墨的原料、涂层的原料、粘合剂的原料、环氧树脂的原料、光刻胶或抗氧化剂的原料以及功能聚合物的起始原料。
• PROCESS FOR PRODUCING A RESIN COMPOSITION
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1114836B1

  公开（公告）日：2006-11-08
• US6344516B1
  申请人：——

  公开号：US6344516B1

  公开（公告）日：2002-02-05
• Schindler, Siegfried; Elias, Horst; Paulus, Helmut, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1990, vol. 45, # 5, p. 607 - 618
  作者：Schindler, Siegfried、Elias, Horst、Paulus, Helmut

  DOI：——

  日期：——