8-hydroxy-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one | 104665-65-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 8-hydroxy-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
• 英文别名: 8-hydroxy-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one；8-Hydroxy-6,7-dimethoxy-3,4-dihydro-2H-naphthalin-1-on；8-hydroxy-6,7-dimethoxy-3,4-dihydro-2H-naphthalen-1-one
• CAS: 104665-65-8
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: PVQAQGFHLHLRSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6,7,8-trimethoxy-3,4-dihydro-2H-naphthalene-1-one 在 氢溴酸 、 溶剂黄146 作用下， 生成 8-hydroxy-6,7-dimethoxy-3,4-dihydronaphthalen-1(2H)-one
  参考文献：
  名称：

  Notes - Hydrogen Bromide-Acetic Acid Cleavage of Several Methoxyindanones and Methoxytetralones

  摘要：

  DOI：

  10.1021/jo01097a609

文献信息

• Formal Total Synthesis of Actinoranone: Synthesis Approaches and Cytotoxic Studies
  作者：Luiz F. T. Novaes、Kaliandra de Almeida Gonçalves、Daniela B. B. Trivella、Julio C. Pastre

  DOI：10.1021/acs.joc.8b00514

  日期：2018.5.4

  toward the total synthesis of actinoranone. Our synthesis strategies rely on a convergent route to connect the terpenoid and polyketide fragments, employing catalysis and powerful classical reactions for the assembly of these key fragments. A new transformation was disclosed during this work, a domino ring-opening and esterification. Initial cytotoxic studies for the selected synthesis intermediates are

  本文介绍了我们努力合成肌动龙酮的努力。我们的合成策略依赖于收敛路线来连接萜类化合物和聚酮化合物片段，并利用催化作用和强大的经典反应来组装这些关键片段。在这项工作中公开了一种新的转变，即多米诺环的开环和酯化。还介绍了所选合成中间体的初步细胞毒性研究。
• Synthesis of methoxy and hydroxy containing tetralones: versatile intermediates for the preparation of biologically relevant molecules
  作者：Anjan Ghatak、James M. Dorsey、Charles M. Garner、Kevin G. Pinney

  DOI：10.1016/s0040-4039(03)00715-9

  日期：2003.5

  The synthesis of 5-hydroxy-6-methoxy-1-tetralone and the 7-hydroxy regioisomer along with the corresponding 5,7-dihydroxy analog has been achieved using an efficient directed metallation procedure followed by a regioselective methylene oxidation. This methodology represents a general synthetic route for the preparation of highly oxygenated tetralone analogs which are versatile building blocks for the construction of molecules of biological interest. (C) 2003 Elsevier Science Ltd. All rights reserved.
• Notes - Hydrogen Bromide-Acetic Acid Cleavage of Several Methoxyindanones and Methoxytetralones
  作者：W. Horton、Bryant Rossiter

  DOI：10.1021/jo01097a609

  日期：1958.3