3-Allyl-2-hydroxybenzoesaeure | 103203-82-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Allyl-2-hydroxybenzoesaeure
• 英文别名: 3-Hydroxy-2-prop-2-enylbenzoic acid
• CAS: 103203-82-3
• 化学式: C₁₀H₁₀O₃
• mdl: MFCD06203385
• 分子量: 178.188
• InChiKey: PFLUWJYZJHUUJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-allyl-3-hydroxybenzoic acid ethyl ester 在 氢氧化钾 作用下， 以 甲醇 为溶剂， 生成 3-Allyl-2-hydroxybenzoesaeure
  参考文献：
  名称：

  Houry,S. et al., Israel Journal of Chemistry, 1973, vol. 11, p. 805 - 817

  摘要：

  DOI：

文献信息

• SYNTHESIS OF INTERMEDIATES FOR PRODUCING PROSTACYCLIN DERIVATIVES
  申请人：United Therapeutics Corporation

  公开号：US20160107973A1

  公开（公告）日：2016-04-21

  The present disclosure provides regioselective methods for synthesizing intermediates useful in making prostacyclin derivatives, such as treprostinil.

  本公开提供了用于合成中间体的区域选择性方法，这些中间体在制备前列环素衍生物（如曲普罗斯汀）中非常有用。
• [EN] SIMPLE MANUFACTURING AND PURIFICATION TECHNOLOGY FOR HIGH PURITY PROPOFOL<br/>[FR] TECHNOLOGIE DE PRODUCTION ET DE PURIFICATION SIMPLE POUR PROPOFOL DE HAUTE PURETÉ
  申请人：CHODANKAR NANDKUMAR

  公开号：WO2021156776A1

  公开（公告）日：2021-08-12

  A process for manufacturing Pure Propofol with a purity of more than 99.90% is disclosed, said process comprising dissolving Crude Propofol in a solvent in which it is soluble to form a solution, treating the solution with aqueous alkali to form an aqueous alkali layer and a solvent layer, separating the aqueous alkali layer from the solvent layer using a phase separation technique, distilling off the solvent from the solvent layer, and distilling a residue of the solvent containing Propofol using steam or boiling water in a presence of dilute alkali and antioxidant like metabisulfite, under normal pressure or mild vacuum.

  本发明揭示了一种制造纯度高于99.90％的纯丙泊酚的工艺，该工艺包括将粗丙泊酚溶解在其可溶的溶剂中形成溶液，用水性碱处理溶液以形成水性碱层和溶剂层，使用相分离技术将水性碱层与溶剂层分离，从溶剂层中蒸馏出溶剂，并在常压或轻度真空下，使用蒸汽或沸水在稀碱和亚硫酸盐等抗氧化剂的存在下，蒸馏含有丙泊酚的溶剂残留物。
• Cationic substituted benzofurans as antimicrobial agents
  申请人：Tidwell R. Richard

  公开号：US20050197378A1

  公开（公告）日：2005-09-08

  A method of treating a Mycobacterium tuberculosis infection in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of treating microbial infections, including infections from protozoan pathogens, such as Leishmania donovani, Trypanosoma brucei rhodesiense , a Trypanosoma cruzi , and Plasmodium falciparum , and fungal pathogens, such as Candida albicans, Aspergillus fumigatus , and Cryptococcus neoformans , in a subject in need thereof by administering to the subject an effective amount of a cationic substituted benzofuran compound. Methods of synthesizing novel cationic substituted benzofuran compounds and the novel compounds themselves.

  本发明涉及一种治疗需要治疗的主体中的结核分枝杆菌感染的方法，包括向该主体内给予阳离子取代苯并呋喃化合物的有效量。本发明还涉及治疗微生物感染的方法，包括来自原虫病原体的感染，例如Leishmania donovani，Trypanosoma brucei rhodesiense，Trypanosoma cruzi和Plasmodium falciparum，以及真菌病原体，例如Candida albicans，Aspergillus fumigatus和Cryptococcus neoformans，包括向需要治疗的主体内给予阳离子取代苯并呋喃化合物的有效量。本发明还涉及合成新的阳离子取代苯并呋喃化合物的方法以及这些新化合物本身。
• Toughened polyoxymethylene compositions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0116456A1

  公开（公告）日：1984-08-22

  Polyoxymethylene compositions having 15-40 wt. % thermoplastic polyurethane, where the polyurethane has a glass transition of lower than -15°C, the polyoxymethylene has a molecular weight of 20,000-100,000, and the polyurethane is dispersed in the polyoxymethylene as small particles show extraordinary toughness as measured by notched Izod.

  具有 15-40 重量百分比热塑性聚氨酯的聚甲醛组合物，其中聚氨酯的玻璃化转变温度低于 -15°C，聚甲醛的分子量为 20,000-100,000 ，聚氨酯以小颗粒形式分散在聚甲醛中，用缺口伊佐德法测量，显示出非凡的韧性。
• Impact resistant polyoxymethylene compositions
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0117664A1

  公开（公告）日：1984-09-05

  Polyoxymethylene compositions having 5-15 wt.% thermoplastic polyurethane, where the polyurethane has a soft segment glass transition of lower than 0°C, the polyoxymethylene has a molecular weight of 20,000-100,000, and the polyurethane is dispersed in the polyoxymethylene as discrete particles show extraordinary impact resistance as measured by Gardner impact.

  具有 5-15 重量百分比热塑性聚氨酯的聚甲醛组合物，其中聚氨酯的软段玻璃化转变温度低于 0°C，聚甲醛的分子量为 20,000-100,000 ，聚氨酯以离散颗粒的形式分散在聚甲醛中，通过加德纳冲击测量，显示出非凡的抗冲击性。