1,5-di-tert-butyl-2-fluoro-3-methylbenzene | 40585-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,5-di-tert-butyl-2-fluoro-3-methylbenzene
• 英文别名: 3,5-Di-t-butyl-2-fluortoluol；1,5-Ditert-butyl-2-fluoro-3-methylbenzene
• CAS: 40585-20-4
• 化学式: C₁₅H₂₃F
• 分子量: 222.346
• InChiKey: QQCIQGWQVYXCHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,5-di-tert-butyl-2-fluoro-3-methylbenzene 在 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 生成 1,2-Bis(2-fluor-3,5-di-t-butylphenyl)ethan
  参考文献：
  名称：

  Martinson,P., Acta Chemica Scandinavica (1947-1973), 1972, vol. 26, p. 3529 - 3542

  摘要：

  DOI：
• 作为产物：
  描述：

  3,5-二叔丁基甲苯 在 Selectfluor 作用下， 以 乙腈 为溶剂， 反应 12.0h， 生成 1,5-di-tert-butyl-2-fluoro-3-methylbenzene 、 1,3-di-tert-butyl-2-fluoro-5-methylbenzene
  参考文献：
  名称：

  Enantioselective Oxidation of Alkenes with Potassium Permanganate Catalyzed by Chiral Dicationic Bisguanidinium

  摘要：

  Chiral anion-controlled ion-pairing catalysis was demonstrated to be a wide-ranging strategy that can utilize a variety of cationic metal species. In a similar manner, we envision a complementary strategy using chiral cation in partnership with inorganic anionic metal salts. Herein, we report a chiral dicationic bisguanidinium-catalyzed asymmetric oxidation reaction of alkenes with potassium permanganate. Chiral induction is attributed to ion-pairing interaction between chiral cation and enolate anion. The success of the current permanganate oxidation reaction together with mechanistic insights should provide inspiration for expansion to other anionic metal salts and would open up new paradigms for asymmetric transition metal catalysis, phase-transfer catalysis, and ion-pairing catalysis.

  DOI：

  10.1021/jacs.5b05792

文献信息

• Oximide derivatives and their therapeutical application
  申请人：Yu Chang Jun

  公开号：US20090012091A1

  公开（公告）日：2009-01-08

  The present invention relates to a compound represented as the following Formula (I) and a pharmaceutical composition thereof wherein all substituents are as defined in the specification; and also relates to a method for treating or lessening the severity of a disease or a condition, comprising administering said compound or said pharmaceutical composition.

  本发明涉及一种表示为以下化学式（I）的化合物及其药物组合物，其中所有取代基如规范中定义；还涉及一种治疗或减轻疾病或病况严重程度的方法，包括给予该化合物或该药物组合物。
• Enantioselective Oxidation of Alkenes with Potassium Permanganate Catalyzed by Chiral Dicationic Bisguanidinium
  作者：Chao Wang、Lili Zong、Choon-Hong Tan

  DOI：10.1021/jacs.5b05792

  日期：2015.8.26

  Chiral anion-controlled ion-pairing catalysis was demonstrated to be a wide-ranging strategy that can utilize a variety of cationic metal species. In a similar manner, we envision a complementary strategy using chiral cation in partnership with inorganic anionic metal salts. Herein, we report a chiral dicationic bisguanidinium-catalyzed asymmetric oxidation reaction of alkenes with potassium permanganate. Chiral induction is attributed to ion-pairing interaction between chiral cation and enolate anion. The success of the current permanganate oxidation reaction together with mechanistic insights should provide inspiration for expansion to other anionic metal salts and would open up new paradigms for asymmetric transition metal catalysis, phase-transfer catalysis, and ion-pairing catalysis.
• Martinson,P., Acta Chemica Scandinavica (1947-1973), 1972, vol. 26, p. 3529 - 3542
  作者：Martinson,P.

  DOI：——

  日期：——