(2R,4S)-2-methyl-1-(4-methylphenyl)sulfonylpiperidin-4-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2R,4S)-2-methyl-1-(4-methylphenyl)sulfonylpiperidin-4-ol
• 化学式: C₁₃H₁₉NO₃S
• 分子量: 269.365
• InChiKey: NOKADRRUIYQFDZ-NEPJUHHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(3-丁烯-1-基)-4-甲基苯磺酰胺 、 乙醛 在 phosphomolybdic acid 作用下， 以 二氯甲烷 为溶剂， 反应 5.5h， 以79%的产率得到(2R,4S)-2-methyl-1-(4-methylphenyl)sulfonylpiperidin-4-ol
  参考文献：
  名称：

  Heteropoly acid-catalyzed aza-Prins-cyclization: an expeditious synthesis of 4-hydroxypiperidines

  摘要：

  4-Hydroxypiperidines are prepared in good yields and with high selectivity by means of aza-Prins-cyclization using 10 mol % phosphomolybdic acid under mild reaction conditions. This is the first report on the preparation of 4-hydroxypiperidines via aza-Prins-cyclization. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.01.148

文献信息

• Heteropoly acid-catalyzed aza-Prins-cyclization: an expeditious synthesis of 4-hydroxypiperidines
  作者：J.S. Yadav、B.V. Subba Reddy、D.N. Chaya、G.G.K.S. Narayana Kumar、P. Naresh、B. Jagadeesh

  DOI：10.1016/j.tetlet.2009.01.148

  日期：2009.4

  4-Hydroxypiperidines are prepared in good yields and with high selectivity by means of aza-Prins-cyclization using 10 mol % phosphomolybdic acid under mild reaction conditions. This is the first report on the preparation of 4-hydroxypiperidines via aza-Prins-cyclization. (C) 2009 Elsevier Ltd. All rights reserved.