N,N'-Ethylen-2,2'-bis--bis-acetamid | 45278-21-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N'-Ethylen-2,2'-bis--bis-acetamid
• 英文别名: 2-[bis(2-hydroxyethyl)amino]-N-[2-[[2-[bis(2-hydroxyethyl)amino]acetyl]amino]ethyl]acetamide
• CAS: 45278-21-5
• 化学式: C₁₄H₃₀N₄O₆
• 分子量: 350.415
• InChiKey: WQMTZMRUXABNAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  24
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  146
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N,N'-Ethylen-2,2'-bis--bis-acetamid 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 生成 N,N'-Ethylen-2,2'-bis--bisacetamid
  参考文献：
  名称：

  Preparation of Derivatives of Nitrogen Mustard having Structure of α-Amino Acid Amide

  摘要：

  研究人员制备了一些新的双(2-氯乙基)-DL-甘氨酸和双(2-氯乙基)-DL-丙氨酸酰胺衍生物，并测试了它们对吉田肉瘤的体内和体外抗肿瘤活性以及化学特性。

  DOI：

  10.1248/cpb.13.594
• 作为产物：
  描述：

  乙二胺 、 2-[双(2-羟乙基)氨基]乙酰胺 以 水 为溶剂， 生成 N,N'-Ethylen-2,2'-bis--bis-acetamid
  参考文献：
  名称：

  Facile hydrolysis and formation of amide bonds by N-hydroxyethylation of α-amino acids

  摘要：

  The C-terminal amides of alpha-amino acids are readily hydrolyzed at 25 degrees and pH 7 when the N-terminus is N-hydroxyethylated, with one or two hydroxyethyl groups. The reaction proceeds via cyclization to a morpholinolactone (2) which is rapidly hydrolyzed by water. In the presence of equimolar amounts of amines or amino acid derivatives, 2 reacts in H2O without condensing agents to form a new peptide bond. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00330-4

文献信息

• Facile hydrolysis and formation of amide bonds by N-hydroxyethylation of α-amino acids
  作者：J.William Suggs、Richard M. Pires

  DOI：10.1016/s0040-4039(97)00330-4

  日期：1997.3

  The C-terminal amides of alpha-amino acids are readily hydrolyzed at 25 degrees and pH 7 when the N-terminus is N-hydroxyethylated, with one or two hydroxyethyl groups. The reaction proceeds via cyclization to a morpholinolactone (2) which is rapidly hydrolyzed by water. In the presence of equimolar amounts of amines or amino acid derivatives, 2 reacts in H2O without condensing agents to form a new peptide bond. (C) 1997 Elsevier Science Ltd.
• Preparation of Derivatives of Nitrogen Mustard having Structure of α-Amino Acid Amide
  作者：Yoshio Sakurai、Eiichi Matsui

  DOI：10.1248/cpb.13.594

  日期：——

  A number of new amide derivatives of bis(2-chloroethyl)-DL-glycine and bis(2-chloroethyl)-DL-alanine were prepared and tested for their in vivo and in vitro antitumor activity against Yoshida Sarcoma, and chemical properties.

  研究人员制备了一些新的双(2-氯乙基)-DL-甘氨酸和双(2-氯乙基)-DL-丙氨酸酰胺衍生物，并测试了它们对吉田肉瘤的体内和体外抗肿瘤活性以及化学特性。