1-(2-morpholin-4-yl-ethyl)-3-phenyl-1H-quinazoline-2,4-dione | 55559-10-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1-(2-morpholin-4-yl-ethyl)-3-phenyl-1H-quinazoline-2,4-dione
• 英文别名: 1-(2-morpholinoethyl)-3-phenylquinazoline-2,4(1H,3H)-dione；1-(2-morpholin-4-ylethyl)-3-phenylquinazoline-2,4-dione
• CAS: 55559-10-9
• 化学式: C₂₀H₂₁N₃O₃
• 分子量: 351.405
• InChiKey: RYVVTMBVDLOMOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  53.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(2-氯乙基)吗啉 、 3-苯基-2,4(1H,3H)-喹唑啉二酮 在 sodium ethanolate 作用下， 生成 1-(2-morpholin-4-yl-ethyl)-3-phenyl-1H-quinazoline-2,4-dione
  参考文献：
  名称：

  Lespagnol; Bernier; Lespagnol, European Journal of Medicinal Chemistry, 1974, vol. 9, # 3, p. 263 - 268

  摘要：

  DOI：

文献信息

• [EN] METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS<br/>[FR] PROCÉDÉS ET MATÉRIAUX POUR AUGMENTER LES NIVEAUX DE POLYPEPTIDES EB DE FACTEUR DE TRANSCRIPTION
  申请人：UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION

  公开号：WO2020142748A1

  公开（公告）日：2020-07-09

  This document provides methods and materials for increasing TFEB polypeptide levels. For example, compounds (e.g., organic compounds) having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for making formulations containing compounds having the ability to increase TFEB polypeptide levels within cells and/or within a nucleus of cells, methods for increasing TFEB polypeptide levels within cells and/or within a nucleus of cells, and methods for treating mammals (e.g., humans) having a condition responsive to an increase in TFEB polypeptide levels are provided.
• Lespagnol; Bernier; Lespagnol, European Journal of Medicinal Chemistry, 1974, vol. 9, # 3, p. 263 - 268
  作者：Lespagnol、Bernier、Lespagnol、et al.

  DOI：——

  日期：——