o-nitrobenzyl methacrylate | 49594-71-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-nitrobenzyl methacrylate
• 英文别名: 2-nitrobenzyl methacrylate；NBMA；(2-Nitrophenyl)methyl 2-methylprop-2-enoate
• CAS: 49594-71-0
• 化学式: C₁₁H₁₁NO₄
• 分子量: 221.213
• InChiKey: WBBKYDCLZKGNSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  邻硝基苯甲醇 、 甲基丙烯酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 生成 o-nitrobenzyl methacrylate
  参考文献：
  名称：

  Triple stimuli-responsive crosslinked polymeric nanoparticles for controlled release

  摘要：

  通过交联 pH、温度和光敏两亲共聚物的自组装，制备了三重刺激响应纳米凝胶。通过交联提高的稳定性和通过组合刺激产生的协同响应性使这种纳米颗粒极有可能成为控制货物释放的新型纳米容器。

  DOI：

  10.1039/c4ra05661b

文献信息

• Orthogonal Procesing of Organic Materials Used in Electronic and Electrical Devices
  申请人：Ober Christopher K.

  公开号：US20110159252A1

  公开（公告）日：2011-06-30

  An orthogonal process for photolithographic patterning organic structures is disclosed. The disclosed process utilizes fluorinated solvents or supercritical CO 2 as the solvent so that the performance of the organic conductors and semiconductors would not be adversely affected by other aggressive solvent. One disclosed method may also utilize a fluorinated photoresist together with the HFE solvent, but other fluorinated solvents can be used. In one embodiment, the fluorinated photoresist is a resorcinarene, but various fluorinated polymer photoresists and fluorinated molecular glass photoresists can be used as well. For example, a copolymer perfluorodecyl methacrylate (FDMA) and 2-nitrobenzyl methacrylate (NBMA) is a suitable orthogonal fluorinated photoresist for use with fluorinated solvents and supercritical carbon dioxide in a photolithography process. The combination of the fluorinated photoresist and the fluorinated solvent provides a robust, orthogonal process that is yet to be achieved by methods or devices known in the art.

  本文介绍了一种用于光刻有机结构的正交工艺。该工艺利用氟化溶剂或超临界CO2作为溶剂，以使有机导体和半导体的性能不受其他侵蚀性溶剂的不利影响。其中一种方法还可以使用氟化光阻与HFE溶剂结合使用，但也可以使用其他氟化溶剂。在一种实施例中，氟化光阻是一种二苯并呋喃酮，但也可以使用各种氟化聚合物光阻和氟化分子玻璃光阻。例如，一种共聚物全氟癸基甲基丙烯酸酯（FDMA）和2-硝基苯甲酸甲酯（NBMA）是用于与氟化溶剂和超临界二氧化碳在光刻工艺中使用的适用于正交的氟化光阻。氟化光阻和氟化溶剂的组合提供了一种强大的正交工艺，这种工艺尚未被已知的方法或设备实现。
• [EN] CELL PENETRATING POLYMERS AND USES THEREOF<br/>[FR] POLYMÈRES PÉNÉTRANT DANS LES CELLULES ET LEURS UTILISATIONS
  申请人：UNIV WARWICK

  公开号：WO2019102224A1

  公开（公告）日：2019-05-31

  Advances in the development of small molecules as highly potent anticancer drugs often face limitations related to their poor solubility, rapid elimination and limited stability in the body. The use of drug carriers may address these challenges by providing a protective shell that enhances solubility and retards clearance from the blood stream. Moreover, incorporation of drug delivery vectors can of introduce functionality and increase the selective accumulation at the specific target site. So-far-neglected, but particularly interesting, are organic nanotubes (NTs) formed by cyclic peptide-polymer conjugates. We present a specifically designed system comprising a self-assembling cyclic peptide core, a functional polymer shell and a highly potent organoiridium candidate drug.

  小分子作为高效的抗癌药物的开发方面的进展，常常面临其在体内溶解度差、迅速代谢和稳定性有限等方面的限制。药物载体的使用可以通过提供保护性外壳来解决这些挑战，增强溶解度并延缓从血液中的清除。此外，药物递送向量的引入可以引入功能性并增加在特定靶点的选择性积累。迄今为止被忽视但特别有趣的是由环肽-聚合物共轭物形成的有机纳米管（NTs）。我们提出了一个特别设计的系统，包括自组装的环肽核心、功能性聚合物外壳和高效的有机铱候选药物。
• Hierarchical Self‐Assembled Photo‐Responsive Tubisomes from a Cyclic Peptide‐Bridged Amphiphilic Block Copolymer
  作者：Jie Yang、Ji‐Inn Song、Qiao Song、Julia Y. Rho、Edward D. H. Mansfield、Stephen C. L. Hall、Megan Sambrook、Feihe Huang、Sébastien Perrier

  DOI：10.1002/anie.201916111

  日期：2020.6.2

  Typically, the morphologies of the self-assembled nanostructures from block copolymers are limited to spherical micelles, wormlike micelles and vesicles. Now, a new generation of materials with unique shape and structures, cylindrical soft matter particles (tubisomes), are obtained from the hierarchical self-assembly of cyclic peptide-bridged amphiphilic diblock copolymers. The capacity of obtained

  通常，由嵌段共聚物形成的自组装纳米结构的形态仅限于球形胶束，蠕虫状胶束和囊泡。现在，从环状肽桥联的两亲性二嵌段共聚物的分层自组装中获得了具有独特形状和结构的新一代材料，即圆柱形软物质颗粒（微晶胞）。评估获得的光响应微管胞体作为潜在药物载体的能力。超分子微管异构体为制造聚合物管状结构铺平了另一种方式，并将扩展工具箱，以合理设计功能性分层纳米结构。
• Multi-responsive nitrobenzene-based amphiphilic random copolymer assemblies
  作者：Hao Wu、Jie Dong、Cancan Li、Yibiao Liu、Ning Feng、Liping Xu、Xiaowei Zhan、Huai Yang、Guojie Wang

  DOI：10.1039/c3cc39043h

  日期：——

  A photo-, acid- and thermo-responsive nitrobenzene-based amphiphilic copolymer was synthesized and the corresponding multi-responsive behavior of the copolymer assemblies was revealed by TEM, DLS and AFM. The morphological changes of the assemblies under multi-stimuli endowed them with a controlled release of encapsulated molecules.

  合成了一种光、酸和热响应性硝基苯基两亲性共聚物，并通过 TEM、DLS 和 AFM 揭示了共聚物组装体的相应多响应行为。在多重刺激下，组装体的形态发生了变化，从而实现了封装分子的可控释放。
• Stimuli-induced multiple dissociation and micellization transitions of random copolymers
  作者：Shasha Li、Guangxin Chen、Zheng Zhou、Qifang Li

  DOI：10.1039/c5ra07158e

  日期：——

  Upon UV irradiation, random copolymer P(NBMA-co-MEO₂MA-co-OEGMA) was converted into P(MAA-co-MEO₂MA-co-OEGMA) with disruption of the initial micelles. Further increasing the temperature or decreasing the pH induced the reformation of micelles.

  在紫外辐射下，随机共聚物P（NBMA-co-MEO₂MA-co-OEGMA）被转化为P（MAA-co-MEO₂MA-co-OEGMA），并破坏了初始胶束。进一步提高温度或降低pH值会诱导胶束的再形成。