6-(di-n-hexylamino)-1-hexanol | 74509-50-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-(di-n-hexylamino)-1-hexanol
• 英文别名: 6-(Dihexylamino)hexan-1-ol
• CAS: 74509-50-5
• 化学式: C₁₈H₃₉NO
• 分子量: 285.514
• InChiKey: QKCCAYRUTOXFIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(di-n-hexylamino)-1-hexanol 在 氯化亚砜 作用下， 生成 6-chloro-N,N-dihexylhexan-1-amine
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004
• 作为产物：
  描述：

  6-氯-1-己醇 、 二已胺 以50%的产率得到6-(di-n-hexylamino)-1-hexanol
  参考文献：
  名称：

  Analogs of 8-[[6-(diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline as candidate antileishmanial agents

  摘要：

  8-[[6-(Diethylamino)hexyl]amino]-6-methoxy-4-methylquinoline (I) has been shown to be highly effective against Leishmania donovani in hamsters, being approximately 475 times as active as the standard meglumine antimoniate. Several nuclear and side-chain analogues of I have been prepared in an attempt to further enhance the antileishmanial activity of this class of compounds. The compounds were tested against L. donovani in the golden hamster. Although several analogues had meglumine antimoniate indexes in excess of 300, none was superior to the model compound.

  DOI：

  10.1021/jm00183a004

文献信息

• PROCESS FOR PREPARING (METH)ACRYLIC ACID
  申请人：Vogel Bernd

  公开号：US20100029979A1

  公开（公告）日：2010-02-04

  The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.

  本发明涉及一种制备（甲基）丙烯酸的方法，其特征在于在催化剂的存在下将环状酯转化为（甲基）丙烯酸。制备的（甲基）丙烯酸可以特别地转化为（甲基）丙烯酸酯。
• PROCESS FOR PREPARING TETRAMETHYL GLYCOLIDE
  申请人：Vogel Bernd

  公开号：US20100010276A1

  公开（公告）日：2010-01-14

  The present invention relates to a process for preparing tetramethylglycolide by heating a composition which comprises at least 50% by weight of 2-hydroxy-isobutyric acid and/or tetramethylglycolide to a temperature of at least 100° C.

  本发明涉及一种制备四甲基乙二酰乙酯的方法，包括将含有至少50%重量的2-羟基异丁酸和/或四甲基乙二酰乙酯的组合物加热至至少100℃的温度。
• Recombinant cell producing 2-hydroxyisobutyric acid
  申请人：Reinecke Liv

  公开号：US10174349B2

  公开（公告）日：2019-01-08

  The invention relates to a cell which has been genetically modified so as to be capable of producing more 2-hydroxyisobutyric acid or more polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units than its wild type, characterized in that 2-hydroxyisobutyric acid or polyhydroxyalkanoates containing 2-hydroxyisobutyric acid monomer units are produced via acetoacetyl-coenzyme A as intermediate and 3-hydroxybutyryl-coenzyme A as precursor.

  本发明涉及一种经过基因修饰的细胞，与野生型相比，该细胞能够产生更多的 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的更多的聚羟基烷酸酯，其特征在于 2-羟基异丁酸或含有 2-羟基异丁酸单体单元的聚羟基烷酸酯是通过乙酰乙酰辅酶 A 作为中间体和 3-羟基丁酰辅酶 A 作为前体产生的。
• DAGLI D.; KHAN M. S.; BLUMBERGS P., J. MED. CHEM., 1980, 23, NO 9, 981-985
  作者：DAGLI D.、 KHAN M. S.、 BLUMBERGS P.

  DOI：——

  日期：——
• VERFAHREN ZUR HERSTELLUNG VON (METH)ACRYLSÄUREESTERN
  申请人：BASF Aktiengesellschaft

  公开号：EP1399408B1

  公开（公告）日：2006-03-22