4,4'-bis(cyanamino)diphenyl ether | 30070-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4,4'-bis(cyanamino)diphenyl ether
• 英文别名: Agn-PC-0NI6VQ；[4-[4-(cyanoamino)phenoxy]phenyl]cyanamide
• CAS: 30070-40-7
• 化学式: C₁₄H₁₀N₄O
• 分子量: 250.26
• InChiKey: KMHUYNPVNWSEQZ-UHFFFAOYSA-N

物化性质

• 熔点：
  155-157 °C
• 沸点：
  391.3±52.0 °C(Predicted)
• 密度：
  1.347±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4,4'-bis(cyanamino)diphenyl ether 在 盐酸羟胺 、 potassium carbonate 作用下， 以 乙醇 为溶剂， 生成 2-[4-[4-[[Amino-(hydroxyamino)methylidene]amino]phenoxy]phenyl]-1-hydroxyguanidine
  参考文献：
  名称：

  Aromatic Bis-N-hydroxyguanidinium Derivatives: Synthesis, Biophysical, and Biochemical Evaluations

  摘要：

  In this paper we report the synthesis of a new family of hydroxyguanidinium aromatic derivatives (4a-g) as potential minor groove binders and cytotoxic agents. Their DNA affinity was evaluated by thermal denaturation experiments using salmon sperm DNA. The antiproliferative effects of derivatives 4a, 4d, and 4f were evaluated in human promyelocytic HL-60, breast carcinoma MCF-7, and neuroblastoma Kelly cell lines using the AlamarBlue viability assay, and IC50 values were obtained. All three compounds were active in the HL-60 cell line. In particular, 4b exhibits antiproliferative effects in all three cell lines while 4d reduced HL-60 and Kelly viability. Both 4b and 4d produced considerable antiproliferative activity in the Kelly cell line. Derivative 4d was chosen for further cell cycle and apoptosis studies using flow cytometric analysis of cellular DNA content.

  DOI：

  10.1021/jm301358s
• 作为产物：
  描述：

  溴化氰 、 4,4'-二氨基二苯醚 以 tetrahydrofyran 为溶剂， 反应 2.0h， 生成 4,4'-bis(cyanamino)diphenyl ether
  参考文献：
  名称：

  一种合成 N-1 取代乙内酰脲的有效方法

  摘要：

  一种有效的三步法合成 N-1 烷基/芳基取代的乙内酰脲是从廉价的市售底物开发出来的。胺与溴化氰反应生成单烷基/芳基氰胺。在四氢呋喃中，在氢化钠存在下用溴乙酸甲酯处理得到 N-氰基-N-烷基/芳基氨基乙酸甲酯，在 50% H2SO4 存在下进行水解和环化，得到 N-1 取代的乙内酰脲。 - 优良的产量。通过该方法成功合成了在 N-1 位具有伯、仲、叔和芳基取代基的多种最终产品。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

  DOI：

  10.1002/ejoc.200701025

文献信息

• Heat-resistant resin, thermosetting composition affording the same and prepolymer thereof
  申请人：HITACHI, LTD.

  公开号：EP0102052A2

  公开（公告）日：1984-03-07

  A polymer having excellent heat resistance and mechanical properties and comprising chemical structural units of the following formulae [I] and [II]: (polymer unit having an isomelamine ring) (polymer unit having a normal melamine ring) wherein A and B each represents an at least divalent organic group having at least one aromatic ring and m and n each represents a number of at least 1.

  一种具有优异耐热性和机械性能的聚合物，由下式[I]和[II]的化学结构单元组成： (具有异戊胺环的聚合物单元） (具有一个普通三聚氰胺环的聚合物单元） 其中 A 和 B 分别代表至少具有一个芳香环的二价有机基团，m 和 n 分别代表至少为 1 的数字。
• Resin encapsulated semiconductor device and process for producing the same
  申请人：HITACHI, LTD.

  公开号：EP0123262A2

  公开（公告）日：1984-10-31

  The resin encapsulated semiconductor device having improved moisture resistance and thermal stability is provided with a resin encapsulation and/or resin coating of a resin material containing isomelamine rings and melamine rings.

  树脂封装半导体器件具有更好的防潮性和热稳定性，其树脂封装和/或树脂涂层是由含有异戊胺环和三聚氰胺环的树脂材料构成的。
• Polyolefin resinsompositions and process for producing same
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0440923A1

  公开（公告）日：1991-08-14

  A resin composition prepared by melting and kneading (A) a thermoplastic resin comprising a polyolefin resin together with (B) a functional compound having one or more bond(s) or one or more functional group(s) selected from non-aromatic carbon-carbon multiple bonds, oxirane groups and substituted carboxyl groups, and subsequently mixing thereinto (C) a polar compound having in one molecule one or more polar group(s) selected from substituted carboxyl groups, substituted hydroxyl groups, substituted amino groups, substituted mercapto groups, substituted sulfonic acid groups, oxazoline groups, isocyanato groups and oxirane groups, provided that at least one of the polar groups of (C) is different from at least one of the functional groups of the functional compound (B), as well as a process for producing said resin composition.

  一种树脂组合物，通过熔化和捏合(A)由聚烯烃树脂组成的热塑性树脂和(B)具有一个或多个键或一个或多个选自非芳香族碳-碳多键、环氧乙烷基团和取代羧基的官能团的功能化合物，并随后混合(C)在一个分子中具有一个或多个选自取代羧基的极性基团的极性化合物而制备、取代的羟基、取代的氨基、取代的巯基、取代的磺酸基、噁唑啉基、异氰酸基和环氧乙烷基，条件是 (C) 的至少一个极性基团与官能团化合物 (B) 的至少一个官能团不同，以及生产所述树脂组合物的工艺。
• Multi-layer wiring substrate and production thereof
  申请人：HITACHI, LTD.

  公开号：EP0476589A2

  公开（公告）日：1992-03-25

  A multi-layer wiring substrate for directly mounting chips or chip carriers obtained by using as adhesive layers and/or insulating layers a cured product of a special ether imide compound alone or together with at least one of aromatic cyanamide compounds, cyanurate compounds and cyanate compounds, is excellent in flexibility, solder heat resistance, high temperature fluidity and adhesiveness to copper conductors.

  一种用于直接安装芯片或芯片载体的多层布线基板，是将一种特殊的醚酰亚胺化合物单独或与芳香族氰酰胺化合物、氰尿酸酯化合物和氰酸酯化合物中的至少一种化合物一起作为粘合层和/或绝缘层固化而成的，具有优异的柔韧性、耐焊热性、高温流动性和与铜导体的粘合性。
• PANKRATOV V. A.; KORSHAK V. V.; VINOGRADOVA N. P.; ANTSIFEROVA N. P.; KUT+, IZV. AN CCCP. CEP. XIM. <IASK-A6>, 1975, HO 10, 2315-2316
  作者：PANKRATOV V. A.、 KORSHAK V. V.、 VINOGRADOVA N. P.、 ANTSIFEROVA N. P.、 KUT+

  DOI：——

  日期：——