(R)-2-氨基-3-(3,4-二甲氧基苯基)-2-甲基丙酸乙酯 | 141847-06-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (R)-2-氨基-3-(3,4-二甲氧基苯基)-2-甲基丙酸乙酯
• 英文名称: (R)-2-Amino-3-(3,4-dimethoxy-phenyl)-2-methyl-propionic acid ethyl ester
• 英文别名: ethyl (2R)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropanoate
• CAS: 141847-06-5
• 化学式: C₁₄H₂₁NO₄
• 分子量: 267.325
• InChiKey: AMWBYZBGGBIWGA-CQSZACIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,4-Dimethoxy-α-methyl-phenylalanin-ethylester 以 various solvent(s) 为溶剂， 生成 (2S)-2-氨基-3-(3,4-二甲氧基苯基)-2-甲基丙酸 、 (R)-2-氨基-3-(3,4-二甲氧基苯基)-2-甲基丙酸乙酯
  参考文献：
  名称：

  Biocatalytic resolution of tertiary .alpha.-substituted carboxylic acid esters: efficient preparation of a quaternary asymmetric carbon center

  摘要：

  A method for resolving a variety of tertiary alpha-substituted carboxylic acid

  DOI：

  10.1021/jo00039a004

文献信息

• EP1981831A2
  申请人：——

  公开号：EP1981831A2

  公开（公告）日：2008-10-22
• Kit for automated resolving agent selection and method thereof
  申请人：Vaidya A. Niteen

  公开号：US20070185346A1

  公开（公告）日：2007-08-09

  The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 24, 48, 96 or more samples is examined simultaneously visually or by standard analytical techniques.
• KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF
  申请人：Vaidya Niteen A.

  公开号：US20120041225A1

  公开（公告）日：2012-02-16

  The present invention provides a means for the rapid selection of optimum resolving agents and solvents, combinations and conditions to separate optical isomers. The present invention combinedly describes and automates a full lifecycle of chiral separation method development and optimization through a series of kits and procedures providing screening, automation for screening, racemate recovery, enantiomer preparation, and method optimization.
• [EN] KIT FOR AUTOMATED RESOLVING AGENT SELECTION AND METHOD THEREOF<br/>[FR] KIT POUR LA SELECTION AUTOMATISEE D'AGENTS DE RESOLUTION ET SON PROCEDE
  申请人：VAIDYA NITEEN A

  公开号：WO2007092264A2

  公开（公告）日：2007-08-16

  (EN) The present invention concerns an improved method and a tray or kit, which is useful to select quickly the optimum resolution agents, combinations and conditions to separate optical isomers. The tray of 12, 24, 48, 96 or more samples is examined simultaneously visually or by standard analytical techniques.(FR) La présente invention concerne un procédé amélioré et un plateau ou kit, qui est utile afin de sélectionner rapidement les agents de résolution, combinaisons et conditions optimums pour séparer des isomères optiques. Le plateau de 12, 24, 48, 96 ou plus échantillons est examiné simultanément visuellement ou par des techniques analytiques standard.
• Biocatalytic resolution of tertiary .alpha.-substituted carboxylic acid esters: efficient preparation of a quaternary asymmetric carbon center
  作者：Christopher Yee、Todd A. Blythe、Thomas J. McNabb、Alan E. Walts

  DOI：10.1021/jo00039a004

  日期：1992.6

  A method for resolving a variety of tertiary alpha-substituted carboxylic acid