4-vinyl-aniline; hydrochloride | 111981-34-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-vinyl-aniline; hydrochloride
• 英文别名: 4-Vinyl-anilin; Hydrochlorid；p-aminostyrene hydrochloride；4-aminostyrene hydrochloride；(4-ethenylphenyl)azanium;chloride
• CAS: 111981-34-1
• 化学式: C₈H₉N*ClH
• 分子量: 155.627
• InChiKey: SFEFZLHQUBUCKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.33
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-iodobenzyl)piperidin-4-one 、 异氰环已烷 、 tert-butylammonium isocyanate 、 4-vinyl-aniline; hydrochloride 以 甲醇 为溶剂， 反应 72.25h， 生成 4-(cyclohexylamino)-8-(4-iodobenzyl)-1-(4-vinylphenyl)-1,3,8-triazaspiro[4.5]dec-3-en-2-one
  参考文献：
  名称：

  WO2008/45250

  摘要：

  公开号：

文献信息

• MACROCYCLIC SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE
  申请人：Nantermet Philippe G.

  公开号：US20100029701A1

  公开（公告）日：2010-02-04

  The present invention is directed to compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.

  本发明涉及式(I)化合物，其是beta-分泌酶酶的抑制剂，适用于治疗涉及beta-分泌酶酶的疾病，如阿尔茨海默病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在涉及beta-分泌酶酶的疾病治疗中的使用。
• Sheet or web material having antistatic properties
  申请人：AGFA-GEVAERT naamloze vennootschap

  公开号：EP0554588A1

  公开（公告）日：1993-08-11

  A sheet or web material comprising a hydrophobic resin support or paper support coated with at least one hydrophobic resin layer wherein said resin support or resin layer is coated with a transparent antistatic layer containing as an essential component a polythiophene with conjugated polymer backbone in the presence of a polymeric polyanion compound, characterized in that said antistatic layer is coated with an overlying adhering barrier layer applied from an aqueous polymer dispersion wherein the dispersed polymer has hydrophilic functionality sufficient to render said overlying layer adherent to a thereon coated hydrophilic colloid-containing layer.

  一种薄片或卷筒材料，包括至少涂有一层疏水性树脂层的疏水性树脂支架或纸支架，其中所述树脂支架或树脂层上涂有一层透明的抗静电层，该层的主要成分是在聚合物聚阴离子化合物存在下具有共轭聚合物骨架的聚噻吩、其特征在于，在所述抗静电层上涂覆一层由水性聚合物分散体制成的附着阻隔层，其中分散聚合物具有亲水功能，足以使所述附着层附着在其上涂覆的含亲水胶体层上。
• Photographic elements comprising antistatic layers
  申请人：MINNESOTA MINING AND MANUFACTURING COMPANY

  公开号：EP0704755A1

  公开（公告）日：1996-04-03

  Light-sensitive photographic element comprising a polymeric film base, a silver halide emulsion layer, and an antistatic layer comprising a low viscosity and highly sulfonated water soluble polyacetal (preferably obtained by reaction of a low viscosity polyvinyl alcohol and a sulfonated aldehyde), a hydrophobic binder selected from the group consisting of a water dispersible sulfopolyester and a latex polymer having hydrophilic functionality, and a polyfunctional aldehyde crosslinking agent. The antistatic layer may be present as a backing layer on the side of the base opposite the silver halide emulsion layer, as a subbing layer between the base and the emulsion layer in a single or double side coated photographic element, and/or as a subbing layer between the base and a different backing layer.

  感光照相元件，包括聚合物膜基、卤化银乳剂层和抗静电层，抗静电层包括低粘度和高磺化的水溶性聚缩醛（最好是由低粘度聚乙烯醇和磺化醛反应得到）、从水分散性聚硫酯和具有亲水功能的乳胶聚合物组成的组中选出的疏水粘合剂以及多官能醛交联剂。抗静电层可以作为底座上与卤化银乳剂层相对的一面的背衬层，也可以作为单面或双面涂层感光元件中底座与乳剂层之间的辅助层，和/或作为底座与不同背衬层之间的辅助层。
• Primer composition for polyesters
  申请人：EASTMAN KODAK COMPANY

  公开号：EP1403702A2

  公开（公告）日：2004-03-31

  A composition suitable for forming a primer layer on a polymer sheet comprising: a) polyethyleneimine; b) latex; wherein the latex has a Tg lower than 25 °C and c) a hydrophilic colloid material. A method of coating the composition is also disclosed.

  一种适用于在聚合物薄片上形成底层的组合物，包括：a) 聚乙烯亚胺；b) 胶乳；其中胶乳的 Tg 低于 25 °C；c) 亲水胶体材料。还公开了一种涂覆该组合物的方法。
• Adhesion promoting polymeric materials
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0213896B1

  公开（公告）日：1992-01-22