N,N-dimethyl-4-phenylcyclohexanamine | 26390-34-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-4-phenylcyclohexanamine
• 英文别名: N,N-dimethyl-4-phenylcyclohexan-1-amine
• CAS: 26390-34-1
• 化学式: C₁₄H₂₁N
• mdl: MFCD14583021
• 分子量: 203.327
• InChiKey: WZUWVVYWGDEWBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1,1-triphenyl-14,17,20,23-tetraoxa-2-thiapentacosan-25-yl methanesulphonate 、 N,N-dimethyl-4-phenylcyclohexanamine 以 乙醇 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  Enzyme-Amplified Array Sensing of Proteins in Solution and in Biofluids

  摘要：

  We have developed an enzyme-nanoparticle sensor array where the sensitivity is amplified through enzymatic catalysis. In this approach cationic gold nanoparticles are electrostatically bound to an enzyme (beta-galactosidase, beta-Gal), inhibiting enzyme activity. Analyte proteins release the beta-Gal, restoring activity and providing an amplified readout of the binding event. Using this strategy we have been able to identify proteins in buffer at a concentration of 1 nM, substantially lower than current strategies for array-based protein sensing. Moreover, we have obtained identical sensitivity in studies where the proteins are spiked into the complex protein matrix provided by desalted human urine (similar to 1.5 mu M total protein; spiked protein concentrations were 0.067% of the overall protein concentration), demonstrating the potential of the method for diagnostic applications.

  DOI：

  10.1021/ja1006756
• 作为产物：
  描述：

  4-苯基环己酮 、 N,N-二甲基甲酰胺 在 zirconium(IV) oxide 作用下， 160.0 ℃ 、300.01 kPa 条件下， 反应 6.0h， 生成 N,N-dimethyl-4-phenylcyclohexanamine
  参考文献：
  名称：

  以四方二氧化锆为多相催化剂对脂肪醛和脂环族酮的选择性还原胺化

  摘要：

  以四方二氧化锆（t -ZrO 2）为催化剂，可实现脂肪族醛和脂环族酮的选择性还原胺化。当使用N，N-二甲基甲酰胺（DMF）作为溶剂，低分子量胺源和还原剂时，N，N-二甲基戊-1-胺或N，N-二甲基环己胺的收率超过99％。正戊醛或环己酮用作底物。特别地，晶体结构对催化性能表现出显着影响，其中四方晶体优选于在还原胺化反应过程中是单斜的。另外，催化剂的再循环实验表明，即使被重复使用五次，t -ZrO 2仍保持高催化活性。从DFT计算的结果可以得出结论，二氧化锆的晶体与催化剂和吸附的反应物之间的电荷转移速率密切相关。最后，根据实验现象和模拟结果，提出了可能的环己酮还原胺化反应机理。

  DOI：

  10.1016/j.mcat.2020.111108

文献信息

• 10.1016/j.apcata.2024.119884
  作者：Han, Tianchen、Wang, Yiming、Yu, Wenqian、Liu, Yuqing、Guo, Rongxiu、Chen, Xin、Zhang, Wenhui、Jiang, Tong、Du, Cengceng、Sun, Hong-bin

  DOI：10.1016/j.apcata.2024.119884

  日期：——
• Enzyme-Amplified Array Sensing of Proteins in Solution and in Biofluids
  作者：Oscar R. Miranda、Hung-Ting Chen、Chang-Cheng You、David E. Mortenson、Xiao-Chao Yang、Uwe H. F. Bunz、Vincent M. Rotello

  DOI：10.1021/ja1006756

  日期：2010.4.14

  We have developed an enzyme-nanoparticle sensor array where the sensitivity is amplified through enzymatic catalysis. In this approach cationic gold nanoparticles are electrostatically bound to an enzyme (beta-galactosidase, beta-Gal), inhibiting enzyme activity. Analyte proteins release the beta-Gal, restoring activity and providing an amplified readout of the binding event. Using this strategy we have been able to identify proteins in buffer at a concentration of 1 nM, substantially lower than current strategies for array-based protein sensing. Moreover, we have obtained identical sensitivity in studies where the proteins are spiked into the complex protein matrix provided by desalted human urine (similar to 1.5 mu M total protein; spiked protein concentrations were 0.067% of the overall protein concentration), demonstrating the potential of the method for diagnostic applications.
• The selective reductive amination of aliphatic aldehydes and cycloaliphatic ketones with tetragonal zirconium dioxide as the heterogeneous catalyst
  作者：Shun Wang、Jiacong Li、Ming Zhang、Peng Bai、Haigang Zhang、Xinli Tong

  DOI：10.1016/j.mcat.2020.111108

  日期：2020.10

  A selective reductive amination of aliphatic aldehydes and cycloaliphatic ketones is achieved with tetragonal zirconium dioxide (t-ZrO2) as the catalyst. With N, N-dimethyl formamide (DMF) as the solvent, low-molecular-weight amine source and reductant, a more than 99 % yield of N, N-dimethylpentan-1-amine or N, N-dimethyl cyclohexanamine was obtained when n-pentanal or cyclohexanone was used as the

  以四方二氧化锆（t -ZrO 2）为催化剂，可实现脂肪族醛和脂环族酮的选择性还原胺化。当使用N，N-二甲基甲酰胺（DMF）作为溶剂，低分子量胺源和还原剂时，N，N-二甲基戊-1-胺或N，N-二甲基环己胺的收率超过99％。正戊醛或环己酮用作底物。特别地，晶体结构对催化性能表现出显着影响，其中四方晶体优选于在还原胺化反应过程中是单斜的。另外，催化剂的再循环实验表明，即使被重复使用五次，t -ZrO 2仍保持高催化活性。从DFT计算的结果可以得出结论，二氧化锆的晶体与催化剂和吸附的反应物之间的电荷转移速率密切相关。最后，根据实验现象和模拟结果，提出了可能的环己酮还原胺化反应机理。