2-氨基己烷-3-醇 | 13325-11-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氨基己烷-3-醇
• 英文名称: 2-amino-hexan-3-ol
• 英文别名: 2-amino-3-hexanol；2-aminohexan-3-ol
• CAS: 13325-11-6
• 化学式: C₆H₁₅NO
• 分子量: 117.191
• InChiKey: TXRCHGMTTXKTPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氨基己烷-3-醇 生成 4-nitro-benzoic acid-(2-hydroxy-1-methyl-pentylamide)
  参考文献：
  名称：

  Dornow; Gellrich, Justus Liebigs Annalen der Chemie, 1955, vol. 594, p. 177,181

  摘要：

  DOI：
• 作为产物：
  描述：

  2-nitro-hexan-3-ol 在 溶剂黄146 、 异丙醇 、 锌 作用下， 生成 2-氨基己烷-3-醇
  参考文献：
  名称：

  ALIPHATIC AMINES OF PHARMACOLOGIC INTEREST. I. 2-AMINO ALKANOLS AND THEIR DERIVATIVES²

  摘要：

  DOI：

  10.1021/jo01137a019

文献信息

• [EN] TRICYCLIC GYRASE INHIBITORS FOR USE AS ANTIBACTERIAL AGENTS<br/>[FR] INHIBITEURS TRICYCLIQUES DE GYRASE UTILISABLES COMME AGENTS ANTIBACTÉRIENS
  申请人：TRIUS THERAPEUTICS INC

  公开号：WO2014043272A1

  公开（公告）日：2014-03-20

  Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors. In addition, species of tricyclic gyrase inhibitors compounds are also disclosed herein. Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

  本文披露了具有化学式I结构的化合物及其药用盐、酯和前药，这些化合物可用作抗菌有效的三环酶抑制剂。此外，本文还披露了三环酶抑制剂化合物的种属。还考虑了相关的药用组合物、用途和制备这些化合物的方法。
• Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
  申请人：3-Dimensional Pharmaceuticals, Inc.

  公开号：US20030105111A1

  公开（公告）日：2003-06-05

  The present invention is directed to a compound of Formula I: 1 wherein A, R 1 , and R 2 are defined herein. The present invention is also directed to compositions comprising compounds of Formula I, methods of using compounds of Formula I, and methods of making compounds of Formula I.

  本发明涉及一种具有以下结构的化合物：其中A、R1和R2在此处被定义。本发明还涉及包含Formula I化合物的组合物、使用Formula I化合物的方法以及制备Formula I化合物的方法。
• Process for the preparation of substituted phenylboronic acids
  申请人：Clariant GmbH

  公开号：US20030220516A1

  公开（公告）日：2003-11-27

  Compounds of the formula (I) 1 in which Q 1 and Q 2 are each OH or form a trimeric boric anhydride, Z is CHO, CH 2 Y, X or a protected aldehyde group, and X is CN, COOH, COCl, CONH 2 or C(OR) 3 , and Y is OH or NH 2 , and Z is in the o-, m- or p-position to the boronic acid radical, are prepared by a) reacting a compound of the formula (II) 2 with Mg in the presence of an anthracene compound and, if desired, a transition-metal halide and, if desired, an Mg halide or in the presence of a transition-metal halide and, if desired, an Mg halide, to give the corresponding arylmagnesium chloride, b) reacting the latter with a borate of the formula B(OR′) 3 and hydrolyzing the product, with removal of the aldehyde protecting group, c) and, if desired, oxidizing or reducing the free aldehyde group.

  化学式(I)的化合物1中，其中Q1和Q2均为OH或形成三聚硼酸酐，Z为CHO、CH2Y、X或受保护的醛基团，X为CN、COOH、COCl、CONH2或C(OR)3，Y为OH或NH2，Z在硼酸基团的o-、m-或p-位置上，通过以下步骤制备：a) 在蒽化合物存在下，将化合物(II)2与Mg反应，如果需要，加入过渡金属卤化物和Mg卤化物，或在过渡金属卤化物存在下，如果需要，加入Mg卤化物，得到相应的芳基氯化镁；b) 将后者与化学式为B(OR′)3的硼酸酯反应，并水解产物，去除醛保护基团；c) 如果需要，氧化或还原自由醛基团。
• AMINOALCOHOL AND BIOCIDE COMPOSITIONS FOR AQUEOUS BASED SYSTEMS
  申请人：Coburn Charles E.

  公开号：US20100093736A1

  公开（公告）日：2010-04-15

  Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I); wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein.

  生物杀灭组合物及其在水介质中的使用，例如金属加工液，所述组合物包括生物杀灭剂；以及式（I）的非生物杀灭主要氨基醇化合物；其中R1、R2、R3、R4和R5的定义如此处所述。
• CORROSION AND MICROBIAL CONTROL IN HYDROCARBONACEOUS COMPOSITIONS
  申请人：Tinetti Sheila M.

  公开号：US20100242341A1

  公开（公告）日：2010-09-30

  Provided are additives of formula I for use in hydrocarbonaceous compositions, such as petroleum or liquid fuels: (I) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein. The additives improve the corrosion resistance of the compositions and, when the composition is biodiesel, also improve microbial resistance. The additives further enhance the antimicrobial efficacy of any added biocides contained in such compositions.

  提供的是I式添加剂，用于烃类组分，例如石油或液体燃料：（I）其中R1，R2，R3，R4和R5的定义如本文所述。这些添加剂可以提高组分的耐腐蚀性，在组分为生物柴油时还可以提高微生物抗性。这些添加剂还可以增强组分中任何添加的杀菌剂的抗菌功效。