2-氨基己-5-烯-1-醇 | 89584-04-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 2-氨基己-5-烯-1-醇
• 英文名称: 2-aminohex-5-en-1-ol
• 英文别名: 2-Amino-hexen-(5)-ol-(1)
• CAS: 89584-04-3
• 化学式: C₆H₁₃NO
• 分子量: 115.175
• InChiKey: XRZOFEYIXZMXAT-UHFFFAOYSA-N

物化性质

• 沸点：
  80-81 °C(Press: 1.5 Torr)
• 密度：
  0.912 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-氨基己-5-烯-1-醇 在 四丁基氟化铵 、 potassium carbonate 、 caesium carbonate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 反应 10.5h， 生成 ethyl N-[6-amino-2-(1-hydroxyhex-5-en-2-ylamino)-5-nitropyrimidin-4-yl]-N-[(3-prop-2-enoxyphenyl)methyl]carbamate
  参考文献：
  名称：

  [EN] MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS
  [FR] PURINES MACROCYCLIQUES DESTINÉES AU TRAITEMENT D'INFECTIONS VIRALES

  摘要：

  这项发明涉及具有式(I)的大环嘌呤衍生物，其制备方法，药物组合物以及它们在治疗病毒感染中的应用。

  公开号：

  WO2014009509A1
• 作为产物：
  描述：

  (+/-)-6-Brom-5-succinimido-hex-1-en 生成 2-氨基己-5-烯-1-醇
  参考文献：
  名称：

  Guillemonat,A.; Peiffer,G., Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1961, vol. 253, p. 2538 - 2539

  摘要：

  DOI：

文献信息

• Reaction Control in Synthetic Organic Photochemistry: Switching between [5+2] and [2+2] Modes of Cycloaddition
  作者：Claudio Roscini、Kara L. Cubbage、Malcolm Berry、Andrew J. Orr-Ewing、Kevin I. Booker-Milburn

  DOI：10.1002/anie.200904059

  日期：2009.11.2

  Split personality: Reaction conditions that enable powerful control over the mode of photocycloaddition in maleimides have been developed. Direct irradiation favors the [5+2] mode whereas sensitized irradiation allows a complete switch to the [2+2] mode (see scheme; TBS=tert‐butyldimethylsilyl).

  人格分裂：已开发出能够有效控制马来酰亚胺中光环加成模式的反应条件。直接辐射有利于[5 + 2]模式，而敏化辐射则允许完全切换到[2 + 2]模式（请参阅方案； TBS =叔丁基二甲基甲硅烷基）。
• Macrocyclic purines for the treatment of viral infections
  申请人：Janssen Sciences Ireland UC

  公开号：US10280180B2

  公开（公告）日：2019-05-07

  This invention relates macrocyclic purine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

  本发明涉及大环嘌呤衍生物、其制备工艺、药物组合物及其在治疗病毒感染中的用途。
• MACROCYCLIC PURINES FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：Janssen Sciences Ireland UC

  公开号：EP2872515B1

  公开（公告）日：2016-06-08
• Golf ball layers formed of polyurethane-based and polyurea-based compositions incorporating block copolymers
  申请人：——

  公开号：US20040262808A1

  公开（公告）日：2004-12-30

  Golf equipment having improved cut and shear resistance that includes a polyurea-based composition or polyurethane-based composition, preferably saturated and/or water resistant, formed of a prepolymer, a functionalized block copolymer, and optionally further cured or chain extended with a curing agent, where the prepolymer is incorporated at the terminal end of the functionalized block copolymer.
• Golf Ball Layers Formed of Polyurethane-Based and Polyurea-Based Compositions Incorporating Block Copolymers
  申请人：Wu Shenshen

  公开号：US20090137342A1

  公开（公告）日：2009-05-28

  A golf ball including a core and a cover, wherein cover is formed from a composition comprising the reaction product of a prepolymer including a soft-segment comprising an amine-terminated polyether and a hard segment including a uretdione of hexamethylene diisocyanate; and an amine-terminated curing agent; wherein the amine-terminated polyether has the structure: where x and z have a combined value of 3.6-8 and y is 9-50, R is an alkyl group having 1-20 carbons, a phenyl group, a cyclic group, or mixtures thereof, R 1 is —(CH 2 ) a —, where a is 1-10, a phenylene group, a cyclic group, or a mixture thereof, and R 3 is hydrogen, a methyl group, or a mixture thereof.