4-Methyl-6-(2-methylpropyl)2-(2,5-dimethylpyrrol-1-yl)pyridine | 179554-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Methyl-6-(2-methylpropyl)2-(2,5-dimethylpyrrol-1-yl)pyridine
• 英文别名: 4-Methyl-6-(2-methylpropyl)-2-(2,5-dimethylpyrrol-1-yl)pyridine；2-(2,5-dimethylpyrrol-1-yl)-4-methyl-6-(2-methylpropyl)pyridine
• CAS: 179554-86-0
• 化学式: C₁₆H₂₂N₂
• 分子量: 242.364
• InChiKey: PIVLYMJCEMASTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  17.8
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-Methyl-6-(2-methylpropyl)2-(2,5-dimethylpyrrol-1-yl)pyridine 在 盐酸羟胺 作用下， 以 乙醇 为溶剂， 生成 2-amino-4-methyl-6-(2-methylpropyl)pyridine
  参考文献：
  名称：

  Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

  摘要：

  A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00389-9
• 作为产物：
  描述：

  2-(2,5-dimethyl-1H-pyrrol-1-yl)-4,6-dimethylpyridine 、 alkaline earth salt of/the/ methylsulfuric acid 在 正丁基锂 作用下， 以 乙醚 为溶剂， 生成 4-Methyl-6-(2-methylpropyl)2-(2,5-dimethylpyrrol-1-yl)pyridine
  参考文献：
  名称：

  Substituted 2-aminopyridines as inhibitors of nitric oxide synthases

  摘要：

  A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00389-9

文献信息

• Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
  申请人：Merck & Co., Inc.

  公开号：US05972975A1

  公开（公告）日：1999-10-26

  Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders. ##STR1##

  化合物公式为（I）的2-氨基吡啶衍生物及其药学上可接受的盐，在治疗一氧化氮合酶介导的疾病和紊乱方面已经被发现有用。##STR1##
• RADIOLABELED 2-AMINO-4-ALKYL-6-(HALOALKYL)PYRIDINE COMPOUNDS AND THEIR USE IN DIAGNOSTIC IMAGING
  申请人：Mach Robert H.

  公开号：US20100278751A1

  公开（公告）日：2010-11-04

  Radiolabeled 2-amino-4-alkyl-6-(haloalkyl)pyridine compounds are disclosed. In some aspects, the compounds bind to inducible nitric oxide synthase (iNOS) with high specificity. In some configurations, a compound comprising a radioisotope can be used for diagnostic imaging of iNOS distribution in a mammalian subject such as a human, using a scanning method such as positron emission tomography (PET scanning). Methods of synthesis of the compounds are also disclosed.
• US5972975A
  申请人：——

  公开号：US5972975A

  公开（公告）日：1999-10-26
• [EN] SUBSTITUTED 2-AMINOPYRIDINES AS INHIBITORS OF NITRIC OXIDE SYNTHASE<br/>[FR] 2-AMINOPYRIDINES SUBSTITUEES UTILISEES COMME INHIBITEURS DE SYNTHASE D'OXYDE D'AZOTE
  申请人：MERCK & CO., INC.

  公开号：WO1996018616A1

  公开（公告）日：1996-06-20

  (EN) Substituted 2-aminopyridine compounds and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders.(FR) Composés de 2-aminopyridine substituée et leurs sels viables sur le plan pharmaceutique pouvant être utilisés dans le traitement de maladies et de troubles dus à la synthase d'oxyde d'azote.
• Substituted 2-aminopyridines as inhibitors of nitric oxide synthases
  作者：William K Hagmann、Charles G Caldwell、Ping Chen、Philippe L Durette、Craig K Esser、Thomas J Lanza、Ihor E Kopka、Ravi Guthikonda、Shrenik K Shah、Malcolm MacCoss、Renee M Chabin、Daniel Fletcher、Stephan K Grant、Barbara G Green、John L Humes、Theresa M Kelly、Sylvie Luell、Roger Meurer、Vernon Moore、Stephen G Pacholok、Tony Pavia、Hollis R Williams、Kenny K Wong

  DOI：10.1016/s0960-894x(00)00389-9

  日期：2000.9

  A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM. (C) 2000 Elsevier Science Ltd. All rights reserved.