4-m-tolylsulfanyl-m-phenylenediamine | 200806-96-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-m-tolylsulfanyl-m-phenylenediamine
• 英文别名: 4-m-Tolylmercapto-m-phenylendiamin；4-(3-methylphenyl)sulfanylbenzene-1,3-diamine
• CAS: 200806-96-8
• 化学式: C₁₃H₁₄N₂S
• 分子量: 230.334
• InChiKey: DRKJWPIBDXWZOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  77.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-Carboxymethoxy-phenyl)-oxo-acetic acid tert-butyl ester 、 4-m-tolylsulfanyl-m-phenylenediamine 在 4-二甲氨基吡啶 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以63%的产率得到{4-[(3-Amino-4-m-tolylsulfanyl-phenylcarbamoyl)-methoxy]-phenyl}-oxo-acetic acid tert-butyl ester
  参考文献：
  名称：

  Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors

  摘要：

  Protein tyrosine phosphatases (PTPases) and protein tyrosine kinase (PTKases) regulate the phosphorylation and dephosphorylation of tyrosine residues in proteins, events that are essential for a variety of cellular functions. PTPases such as PTP1B and the Yersinia PTPase play an important role in diseases including type 11 diabetes and bubonic plague. A library of 67 bidentate PTPase inhibitors that are based on the alpha-ketocarboxylic acid motif has been synthesized using parallel solution-phase methods. Two aryl alpha-ketocarboxylic acids were tethered to a variety of different diamine linkers through amide bonds. The compounds were assayed in crude form against the Yersinia PTPase, PTP1B, and TCPTP. Six compounds were selected for further evaluation, in purified form, against the Yersinia PTPase, PTP1B, TCPTP, LAR, and CD45. These compounds had IC50 values in the low micromolar range against the Yersinia PTPase, PTP I B, and TCPTP, showed good selectivity for PTP1B over LAR, and modest selectivity over CD45. The correlation between linker structure and inhibitor activity shows that aromatic groups in the linker can play an important role in determining binding affinity in this class of inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.02.001
• 作为产物：
  描述：

  (2,4-dinitro-phenyl)-m-tolyl sulfide 在 乙醇 、 镍 作用下， 生成 4-m-tolylsulfanyl-m-phenylenediamine
  参考文献：
  名称：

  Some Basically Substituted Diaryl Sulfides and Sulfones

  摘要：

  DOI：

  10.1021/ja01200a069

文献信息

• Investigations of linker structure on the potency of a series of bidentate protein tyrosine phosphatase inhibitors
  作者：Jian Xie、Christopher T. Seto

  DOI：10.1016/j.bmc.2005.02.001

  日期：2005.4

  Protein tyrosine phosphatases (PTPases) and protein tyrosine kinase (PTKases) regulate the phosphorylation and dephosphorylation of tyrosine residues in proteins, events that are essential for a variety of cellular functions. PTPases such as PTP1B and the Yersinia PTPase play an important role in diseases including type 11 diabetes and bubonic plague. A library of 67 bidentate PTPase inhibitors that are based on the alpha-ketocarboxylic acid motif has been synthesized using parallel solution-phase methods. Two aryl alpha-ketocarboxylic acids were tethered to a variety of different diamine linkers through amide bonds. The compounds were assayed in crude form against the Yersinia PTPase, PTP1B, and TCPTP. Six compounds were selected for further evaluation, in purified form, against the Yersinia PTPase, PTP1B, TCPTP, LAR, and CD45. These compounds had IC50 values in the low micromolar range against the Yersinia PTPase, PTP I B, and TCPTP, showed good selectivity for PTP1B over LAR, and modest selectivity over CD45. The correlation between linker structure and inhibitor activity shows that aromatic groups in the linker can play an important role in determining binding affinity in this class of inhibitors. (c) 2005 Elsevier Ltd. All rights reserved.
• Some Basically Substituted Diaryl Sulfides and Sulfones
  作者：Henry Gilman、H. Smith Broadbent

  DOI：10.1021/ja01200a069

  日期：1947.8