N-(3-Bromopropyl)-4-methylpyridine Bromide | 76780-22-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-(3-Bromopropyl)-4-methylpyridine Bromide
• 英文别名: 1-(3-bromopropyl)-4-methylpyridinium bromide；1-(3-bromopropyl)-4-methylpyridin-1-ium;bromide
• CAS: 76780-22-8
• 化学式: Br*C₉H₁₃BrN
• 分子量: 295.017
• InChiKey: ZGFNOZBLIVXFMY-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.93
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  3.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(3-Bromopropyl)-4-methylpyridine Bromide 在 sodium azide 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以97%的产率得到1-(3-azidopropyl)-4-methylpyridinium bromide
  参考文献：
  名称：

  基于不对称双（苯乙烯基）染料的细胞内 DNA/RNA 分布荧光开启探针

  摘要：

  测试了两种双（苯乙烯基）染料（在两个单（苯乙烯基）单元之间的间隔类型不同）与ct -DNA 或cl -RNA 的相互作用。两种化合物都对 ds-DNA/ss-RNA 表现出很强的亲和力，相互作用的结合模式在 DNA 凹槽结合到 RNA 嵌入之间转变。因此，与 DNA 的相互作用显示出更强的荧光爆发（染料 1 为 151 倍，染料2为 118 倍）) 比与 RNA 结合时（分别为 23 倍和 36 倍）。双（苯乙烯基）系统中能量转移的存在增加了染料的斯托克斯位移，因此当在 370-380 nm 区域照射系统时，在 610-620 nm 处检测到荧光。生物学实验表明，在 DNase 消化试验中观察到有效的细胞内荧光猝灭，这表明染料可以通过在 RNA 分子存在下识别 DNA 来应用。

  DOI：

  10.1016/j.saa.2022.121446
• 作为产物：
  描述：

  1,3-二溴丙烷 、 碳酸甲丙酯 以34%的产率得到
  参考文献：
  名称：

  XARITONOV G. V.; LE CHIN, ZH. ORGAN. XIMII, 1980, 16, HO 11, 2388-2390

  摘要：

  DOI：

文献信息

• Microwave synthesis of the TOTO and BOBO fluorescent probes
  作者：P. A. Sedunova、T. V. Artamonova、S. M. Ramsh

  DOI：10.1007/s11172-012-0118-2

  日期：2012.4

  A series of bis-intercalators of the TOTO and BOBO families (symmetric structures each containing two molecular fragments of nonsymmetric cyanine dyes, viz., Thiazole orange (TO) or Benzothiazole orange (BO)) were synthesized in high yields by the reactions of 1,1′-L-bis-(4-methylpyridinium) derivatives (L is the dicationic linker) with 3-methyl-2-(methylsulfanyl)-benzothiazolium iodide under microwave irradiation.

  通过 1,1′-L-双（4-甲基吡啶鎓）衍生物与噻唑橙（TO）或苯并噻唑橙（BO）的反应，高产率地合成了一系列 TOTO 和 BOBO 家族的双拮抗剂（对称结构，各包含两个非对称氰基染料的分子片段，即在微波辐照下，通过 1,1′-L-双（4-甲基吡啶）衍生物（L 为二阳离子连接体）与 3-甲基-2-（甲硫基）-苯并噻唑鎓碘化物的反应，高产合成了噻唑橙（TO）或苯并噻唑橙（BO）。
• Selective detection of proteins that contain two or more alpha-helical transmembrane domains
  申请人：Patton F. Wayne

  公开号：US20060027455A1

  公开（公告）日：2006-02-09

  Embodiments of the present invention provide a staining solution and of method of using the staining solution for selectively detecting proteins that contain two or more α-helical transmembrane domains. The staining solution comprises a lipophilic dyes and at least about a 30% hydrophobic solvent. The dyes of the present are represented by the general formula A-B-E wherein A is a nitrogen heterocycle, B is a bridge moiety and E is an electron pair accepting moiety that comprises either a carbonyl or nitrogen atom. In one embodiment these lipophilic dyes are merocyanine dye, a cyanine dye, a styryl dye or a carbazolylvinyl dye.

  本发明的实施例提供了一种染色溶液和使用该染色溶液选择性检测含有两个或多个 α-螺旋跨膜结构域的蛋白质的方法。染色溶液包括亲脂性染料和至少约 30%的疏水性溶剂。本发明的染料由通式 A-B-E 表示，其中 A 是氮杂环，B 是桥基，E 是由羰基或氮原子组成的电子对接受基团。在一个实施方案中，这些亲脂性染料是美蓝染料、氰基染料、苯乙烯基染料或咔唑基乙烯基染料。
• Search for the Pharmacophore of Bispyridinium-Type Allosteric Modulators of Muscarinic Receptors
  作者：Mario H. Botero Cid、Ulrike Holzgrabe、Evi Kostenis、Klaus Mohr、Christian Traenkle

  DOI：10.1021/jm00036a008

  日期：1994.5

  The bis(dichlorobenzyl) ether of the bispyridinium oxime TMB 4 stabilizes antagonist binding to M(2)-cholinoceptors which is indicative of an allosteric action. More than 10 derivatives of the lead compound were synthesized to investigate structure-activity relationships. The allosteric potency of the compounds was indicated by the concentrations which retarded the rate of dissociation of [H-3]N-methylscopolamine from porcine cardiac cholinoceptors by a factor of 2 (EC(50)). Compared with TMB 4, the bis(dichlorobenzyl) derivative 4a displayed a more than 200-fold higher potency (EC(50) = 4.7 mu M). One of the dichlorobenzyl groups could be replaced by a methyl group without loss of activity (EC(50) = 4.5 mu M). Further shortening of this end of the molecule was accompanied by a moderate decline in potency to a minimum of EC(50) = 26 mu M. The second quaternary nitrogen was not a prerequisite for an allosteric activity. It is concluded that one half of the lead compound is pivotal for an interaction with the allosteric site of the M(2)-cholinoceptor, whereas the opposite end of the molecule modulates the allosteric activity.
• Kharitonov, G. V.; Ch'in, Lieh, Journal of Organic Chemistry USSR (English Translation), 1980, vol. 16, p. 2044 - 2046
  作者：Kharitonov, G. V.、Ch'in, Lieh

  DOI：——

  日期：——
• Selective Detection of Proteins that Contain Two or More Alpha-Helical Transmembrane Domains
  申请人：Patton Wayne F.

  公开号：US20100267078A1

  公开（公告）日：2010-10-21

  Embodiments of the present invention provide a staining solution and of method of using the staining solution for selectively detecting proteins that contain two or more α-helical transmembrane domains. The staining solution comprises a lipophilic dyes and at least about a 30% hydrophobic solvent. The dyes of the present are represented by the general formula A-B-E wherein A is a nitrogen heterocycle, B is a bridge moiety and E is an electron pair accepting moiety that comprises either a carbonyl or nitrogen atom. In one embodiment these lipophilic dyes are merocyanine dye, a cyanine dye, a styryl dye or a carbazolylvinyl dye.