1-bromo-2-(1-phenyl-1-propen-1-yl)benzene | 304477-55-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-bromo-2-(1-phenyl-1-propen-1-yl)benzene
• CAS: 304477-55-2
• 化学式: C₁₅H₁₃Br
• 分子量: 273.172
• InChiKey: GYOGDKQOQVBXLJ-SILLCRNTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  1-(2-bromophenyl)-1-phenylpropan-1-ol 反应 4.0h， 生成 1-bromo-2-(1-phenyl-1-propen-1-yl)benzene 、 1-bromo-2-(1-phenyl-1-propen-1-yl)benzene
  参考文献：
  名称：

  Synthesis of 1(3H)-Iminobenzo[c]thiophene Derivatives by Hydriodic Acid-mediated Cyclization of 2-(Vinyl)thiobenzamide Derivatives

  摘要：

  Secondary 2-(vinyl)thiobenzamide derivatives, easily prepared by reacting 2-lithiostyrene derivatives with various isothiocyanates, undergo intramolecular cyclization on treatment with concentrated hydriodic acid to produce 1(3H)-iminobenzo[c]thiophene derivatives in fair-to-good yields. Some of them have been hydrolyzed under acidic conditions to afford benzo[c]thiophen-1(3H)-one derivatives in good yields.

  DOI：

  10.3987/com-08-11425

文献信息

• Cobalt-Catalyzed Enantio- and Diastereoselective Intramolecular Hydroacylation of Trisubstituted Alkenes
  作者：Junfeng Yang、Alice Rérat、Yang Jie Lim、Corinne Gosmini、Naohiko Yoshikai

  DOI：10.1002/anie.201611518

  日期：2017.2.20

  Enantio‐ and diastereoselective synthesis of trans‐2,3‐disubstituted indanones is achieved by intramolecular hydroacylation of 2‐alkenylbenzaldehydes bearing trisubstituted alkenyl groups under cobalt‐chiral diphosphine catalysis. Notably, a high level of enantioselectivity is induced regardless of the stereochemistry (E/Z ratio) of the alkenyl group of the starting material. Deuterium‐labeling experiments

  对映体和非对映体选择性合成反式-2,3-二取代的茚满酮是通过在钴-手性二膦催化下将带有三取代烯基的2-烯基苯甲醛分子内加氢酰化而实现的。值得注意的是，无论原料的烯基的立体化学（E / Z比）如何，都诱导出高水平的对映选择性。氘标记实验阐明了E和Z异构体的有效反应途径。