替法唑啉 | 1082-56-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 替法唑啉
• 中文别名: 四氢萘甲咪唑
• 英文名称: Thenaphtoxaline
• 英文别名: 2-(5,6,7,8-tetrahydro-naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole；2-(5,6,7,8-tetrahydro-[1]naphthylmethyl)-4,5-dihydro-1H-imidazole；2-(5,6,7,8-Tetrahydro-[1]naphthylmethyl)-4,5-dihydro-1H-imidazol；tefazoline；2-(5,6,7,8-tetrahydronaphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole
• CAS: 1082-56-0
• 化学式: C₁₄H₁₈N₂
• 分子量: 214.31
• InChiKey: RSTAWBICYZRXME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2934999090

反应信息

• 作为产物：
  描述：

  2-四氢萘-1-基乙酸 、 乙二胺 在 盐酸 作用下， 生成 替法唑啉
  参考文献：
  名称：

  Substituted 2-methyl-delta2 imidazolines

  摘要：

  公开号：

  US02778836A1

文献信息

• Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms
  申请人：ASTA Medica Aktiengesellschaft

  公开号：EP0903151A1

  公开（公告）日：1999-03-24

  Pharmaceutical combination, applicable topically, containing a non-sedating antihistamine in combination with an α-adrenergic agonist and optionally conventional physiologically acceptable carriers, diluting agents and auxiliaries substances for the prophylaxis and treatment of allergic and/or vasomotoric rhinitis, conjunctivitis, cold, cold-like and/ or flu symptoms are claimed.

  声明一种适用于局部使用的药物组合，包含非镇静型抗组胺剂与α-肾上腺素受体激动剂的组合，以及可选的传统生理上可接受的载体、稀释剂和辅助物质，用于预防和治疗过敏性和/或血管运动性鼻炎、结膜炎、感冒、类似感冒和/或流感症状。
• Pharmaceutical preparation comprising an active dispersed on a matrix
  申请人：——

  公开号：US20040058896A1

  公开（公告）日：2004-03-25

  The present invention relates to the field of pharmaceutical technology and describes a novel advantageous preparation for an active ingredient. The novel preparation is suitable for producing a large number of pharmaceutical dosage forms. In the new preparation an active ingredient is present essentially uniformly dispersed in an excipient matrix composed of one or more excipients selected from the group of fatty alcohol, triglyceride, partial glyceride and fatty acid ester.

  本发明涉及制药技术领域，描述了一种新的有利的活性成分制备方法。这种新的制备方法适用于生产大量的药物剂型。在这种新的制备方法中，活性成分基本上均匀地分散在由脂肪醇、甘油三酯、部分甘油酯和脂肪酸酯等多种赋形剂中选择的一种或多种赋形剂组成的赋形剂基质中。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Ophthalmic Formulations Of Cetirizine And Methods Of Use
  申请人：Abelson Mark B.

  公开号：US20110257136A1

  公开（公告）日：2011-10-20

  The present invention provides stable topical formulations of cetirizine that provide a comfortable formulation when instilled in the eye and is effective in the treatment of allergic conjunctivitis and/or allergic conjunctivitis. The invention further provides methods of treating allergic conjunctivitis rhinitis, and/or allergic rhinoconjunctivitis in a subject in need of such treatment by topical application of the cetirizine formulations of the invention directly to the eye.

  本发明提供了稳定的盐酸西替利嗪局部制剂，当滴入眼中时提供舒适的制剂，并且能够有效治疗过敏性结膜炎和/或过敏性结膜炎。本发明还提供了一种通过将本发明的盐酸西替利嗪制剂直接涂抹在眼睛上来治疗需要此类治疗的患者的过敏性结膜炎、鼻炎和/或过敏性鼻结膜炎的方法。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。