2-Triethylsilyl-4-(1-amino-tridecyl)-furan | 130656-94-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-Triethylsilyl-4-(1-amino-tridecyl)-furan
• 英文别名: 4-(1-Aminotridecyl)-2-triethylsilylfuran；1-(5-triethylsilylfuran-3-yl)tridecan-1-amine
• CAS: 130656-94-9
• 化学式: C₂₃H₄₅NOSi
• 分子量: 379.702
• InChiKey: NZYBJTORBKFTLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.31
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Triethylsilyl-4-(1-amino-tridecyl)-furan 、 5,5'-氧双(5-氧代戊酸) 以 甲醇 、 二氯甲烷 为溶剂， 生成 4-[(1-glutarylamido)tridecyl]-2-triethylsilylfuran
  参考文献：
  名称：

  Anti-inflammatory furanones

  摘要：

  新的呋喃酮化合物具有抗炎、免疫抑制和抗增殖活性，并可用于治疗牛皮癣和调节钙稳态。该发明的一种化合物是4-(1-硫代乙酰氧基十三烷基-5-羟基-2(5H)-呋喃酮)。

  公开号：

  US05089485A1
• 作为产物：
  描述：

  4-(1-azidotridecyl)-2-triethylsilylfuran 在 sodium sulfate 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 生成 2-Triethylsilyl-4-(1-amino-tridecyl)-furan
  参考文献：
  名称：

  Intermediates and processes for preparing 4-substituted 2-5(H)-furanones

  摘要：

  抗炎症的4-取代的2-呋喃酮是由具有以下结构的中间体制备的：##STR1## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基；X是H，OH，NH.sub.2，I或Br；R.sub.4是H，1-20个碳原子的烷基，苯基[C.sub.1-C.sub.20烷基]，萘基[C.sub.1-C.sub.20烷基]，CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO，CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5，而R.sub.5是1到6个碳原子的烷基，但当X为氢时，R.sub.4从CH.sub.2 OH，CH.sub.2 NH.sub.2，CH.sub.2 CH.sub.2 OH，CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5的组中选择；##STR2## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.5是1到6个碳原子的烷基；##STR3## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基，而R.sub.6是苯基，或者1到6个碳原子的烷基，以及##STR4## 其中R.sub.1，R.sub.2和R.sub.3独立地是1到6个碳原子的n-烷基，或者1到6个碳原子的支链烷基。

  公开号：

  US05082954A1

文献信息

• Pharmaceutical compositions and method for administering 3 and
  申请人：Allergan, Inc.

  公开号：US05268387A1

  公开（公告）日：1993-12-07

  3 and 4-substituted 2(5H)-furanone compounds influence the balance between bone production and bone resorption in mammals, including humans. The active compounds are administered to mammals, including humans, in an effective dose which ranges between 0.05 to 100 mg per kilogram, body weight, per day, for the purpose of influencing the balance between bone production and bone resorption, and particularly for treating osteoporosis.

  3和4-取代的2(5H)-呋喃酮化合物影响哺乳动物，包括人类的骨生成和骨吸收之间的平衡。这些活性化合物以有效剂量（每公斤体重范围在0.05至100毫克之间）被用于哺乳动物，包括人类，旨在影响骨生成和骨吸收之间的平衡，特别用于治疗骨质疏松症。
• Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates
  申请人：Allergan, Inc.

  公开号：US05169963A1

  公开（公告）日：1992-12-08

  Compounds of the formula ##STR1## in which R.sub.1 independently is H or alkyl of 1 to 29 carbons, CO-R.sub.2, CO-O-R.sub.2, CO-NH-R.sub.2, or PO(OR.sub.2).sub.2 or PO(OR.sub.2)R.sub.2, where R.sub.2 independently is H, alkyl of 1 to 20 carbons, phenyl, or lower alkyl substituted phenyl or halogen substituted phenyl; A is (CH.sub.2).sub.n where n ranges between 0 to 30, or A is a a divalent branch chained alkyl radical, or cycloalkyl radical, having a total of 3 to 30 carbons; R.sub.3 independently is an alkyl group having 4 to 20 carbons, and X is O or NH, have anti-inflammatory activity.

  具有以下结构式的化合物 ##STR1## 中，其中 R.sub.1 独立地为 H 或含有 1 到 29 个碳原子的烷基，CO-R.sub.2，CO-O-R.sub.2，CO-NH-R.sub.2，或 PO(OR.sub.2).sub.2 或 PO(OR.sub.2)R.sub.2，其中 R.sub.2 独立地为 H，含有 1 到 20 个碳原子的烷基，苯基，或取代苯基的较低烷基或卤代苯基；A 为 (CH.sub.2).sub.n，其中 n 范围在 0 到 30 之间，或 A 为二价支链烷基基团，或环烷基基团，总共含有 3 到 30 个碳原子；R.sub.3 独立地为含有 4 到 20 个碳原子的烷基基团，X 为 O 或 NH，具有抗炎活性。
• Intermediates for preparing 4-substituted 2-5(H)-furanones as
  申请人：Allergan, Inc.

  公开号：US05171863A1

  公开（公告）日：1992-12-15

  Anti-inflammatory 4-substituted 2-furanones are made from intermediates having the formulas: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons; X is H, OH, NH.sub.2, I or Br; R.sub.4 is H, alkyl of 1-20 carbons, phenyl[C.sub.1 -C.sub.20 alkyl], naphthyl[C.sub.1 -C.sub.20 alkyl], CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, CH.sub.2 --COOH or CH.sub.2 --COOR.sub.5, and R.sub.5 is alkyl of 1 to 6 carbons, with the proviso that when X is hydrogen then R.sub.4 is selected from the group consisting of CH.sub.2 OH, CH.sub.2 NH.sub.2, CH.sub.2 CH.sub.2 OH, CH.sub.2 --CHO, or CH.sub.2 --COOR.sub.5 ; ##STR2## in which R.sub.1, R.sub.2 R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.5 is alkyl of 1 to 6 carbons; ##STR3## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons, and R.sub.6 is phenyl, or alkyl of 1 to 6 carbons, and ##STR4## in which R.sub.1, R.sub.2 and R.sub.3 independently are n-alkyl of 1 to 6 carbons, or branched chain alkyl of 1 to 6 carbons.

  抗炎4-取代2-呋喃酮是由中间体制备而成，其化学式如下：##STR1## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基；X是H、OH、NH.sub.2、I或Br；R.sub.4是H、1-20个碳的烷基、苯基[C.sub.1-C.sub.20烷基]、萘基[C.sub.1-C.sub.20烷基]、CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO、CH.sub.2 --COOH或CH.sub.2 --COOR.sub.5，其中R.sub.5是1到6个碳的烷基，但是当X是氢时，R.sub.4的选择范围包括CH.sub.2 OH、CH.sub.2 NH.sub.2、CH.sub.2 CH.sub.2 OH、CH.sub.2 --CHO或CH.sub.2 --COOR.sub.5；##STR2## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基，而R.sub.5是1到6个碳的烷基；##STR3## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基，而R.sub.6是苯基或1到6个碳的烷基；##STR4## 其中，R.sub.1、R.sub.2和R.sub.3独立地是1到6个碳的n-烷基，或者是1到6个碳的支链烷基。
• Anti-inflammatory 2-furanones
  申请人：Allergan, Inc.

  公开号：US05045564A1

  公开（公告）日：1991-09-03

  New 2-furanone compounds have calcium channel antagonist activity and are useful as anti-inflammatory agents and in treating psoriasis.

  新的2-呋喃酮化合物具有钙通道拮抗剂活性，可用作抗炎剂和治疗牛皮癣的药物。
• Process of using anti-inflammatory furanones as selective calcium
  申请人：Allergan, Inc.

  公开号：US05376676A1

  公开（公告）日：1994-12-27

  4-(C.sub.10 -C.sub.20)alkyl-2(5H)-furanone compounds are selective calcium channel inhibitors and useful for treatment of diseases such as hypertension, angina, cardiac arrythmia, pulmonary hypertension, aortic insufficiency, Raynand's disease, migraine headaches, deficiency of platelet function, atherosclerosis, ischemia, reprofusion injury, bronchial asthma, esophageal spasm, dysmenorhea, allergic contact dermatitis, acute inflammatory response, glaucoma and as potentiators of chemotherapeutic agents in the treatment of tumors.

  4-(C.sub.10 -C.sub.20)烷基-2(5H)-呋喃酮化合物是选择性钙离子通道抑制剂，可用于治疗高血压、心绞痛、心律失常、肺动脉高压、主动脉瓣不全、雷诺病、偏头痛、血小板功能缺陷、动脉粥样硬化、缺血、再灌注损伤、支气管哮喘、食管痉挛、痛经、过敏性接触性皮炎、急性炎症反应、青光眼以及作为化疗药物增强剂用于肿瘤治疗。