5-Hydroxy-2,3-dimethyl-benzothiophen | 3610-08-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 5-Hydroxy-2,3-dimethyl-benzothiophen
• 英文别名: Benzo[b]thiophene-5-ol, 2,3-dimethyl-；2,3-dimethyl-1-benzothiophen-5-ol
• CAS: 3610-08-0
• 化学式: C₁₀H₁₀OS
• 分子量: 178.255
• InChiKey: PCBCRJRJYVLHLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Hydroxy-2,3-dimethyl-benzothiophen 、 1,1-二苯基-2-丙炔-1-醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 生成 1,2-Dimethyl-7,7-diphenyl-7H-thieno[3,2-f]chromene
  参考文献：
  名称：

  Synthesis of Photochromic Thieno-2H-Chromenes

  摘要：

  DOI：

  10.1080/10426509908546489
• 作为产物：
  描述：

  sodium 4-methoxyphenylthiolate 在 三溴化硼 作用下， 生成 5-Hydroxy-2,3-dimethyl-benzothiophen
  参考文献：
  名称：

  Synthesis of Photochromic Thieno-2H-Chromenes

  摘要：

  DOI：

  10.1080/10426509908546489

文献信息

• 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：EP2360155A1

  公开（公告）日：2011-08-24

  The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is a group such as optionally substituted lower alkyl; R2 is a group such as hydrogen; and R3a and R3b are each independently a group such as hydrogen, provided that the following compound is excluded.

  本发明提供了一种化合物，它具有抑制淀粉样蛋白-β生成的作用，可作为治疗剂用于治疗由淀粉样蛋白-β的生成、分泌和/或沉积诱发的疾病。本发明涉及一种由式（I）代表的化合物或其药学上可接受的盐或溶液： 其中 A 是任选取代的碳环二基或任选取代的杂环二基；B 是任选取代的碳环基团或任选取代的杂环基团；R1 是基团，如任选取代的低级烷基；R2 是基团，如氢；R3a 和 R3b 各自独立地是基团，如氢，但以下化合物除外。
• A Thieno-2<i>H</i>-chromene α-Amino Acid Derivative:  Synthesis and Photochromic Properties
  作者：Maria-João R. P. Queiroz、Ana S. Abreu、Paula M. T. Ferreira、M. Manuel Oliveira、Roger Dubest、Jean Aubard、André Samat

  DOI：10.1021/ol051378a

  日期：2005.10.1

  [GRAPHICS]A new photochromic thieno-2H-chromene a-amino acid derivative was prepared by C-N palladium-catalyzed cross-coupling of a bromothieno-2H-chromene with the aminated aromatic side chain of the methyl ester of a N,N-diprotected amino acid. Its good photochromic properties demonstrated by flash photolysis and continuous irradiation indicate a possible application in ophthalmic lenses. It may also be inserted into peptides to give photoinduced reversible structural changes.
• PHOTOCHROMIC HETEROCYCLOCHROMENES
  申请人：PILKINGTON PLC

  公开号：EP0713489B1

  公开（公告）日：2000-11-02
• SULFONYLPYRROLIDINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
  申请人：SANOFI

  公开号：EP1836180B1

  公开（公告）日：2012-06-13
• 2-AMINOPYRIMIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVES BOTH HAVING BACE1-INHIBITING ACTIVITY
  申请人：Yonezawa Shuji

  公开号：US20110237576A1

  公开（公告）日：2011-09-29

  The present invention provides a compound which has an effect of inhibiting amyloid-β production and is useful as a therapeutic agent for diseases induced by production, secretion and/or deposition of amyloid-β proteins. The present invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein A is optionally substituted carbocyclic diyl or optionally substituted heterocyclic diyl; B is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R 1 is a group such as optionally substituted lower alkyl; R 2 is a group such as hydrogen; and R 3a and R 3b are each independently a group such as hydrogen, provided that the following compound is excluded.