ethyl 3-(N1-imidazo[4,5-b]phenazinyl)propionate | 1021942-69-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 3-(N1-imidazo[4,5-b]phenazinyl)propionate
• CAS: 1021942-69-7
• 化学式: C₁₈H₁₆N₄O₂
• 分子量: 320.351
• InChiKey: CTNOYMGSEKPHAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  24.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  69.9
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  ethyl 3-(N1-imidazo[4,5-b]phenazinyl)propionate 在 乙醇 、 sodium hydroxide 作用下， 反应 0.5h， 以75%的产率得到3-(N1-imidazo[4,5-b]phenazinyl)propionic acid
  参考文献：
  名称：

  Postsynthetic Modification of Oligonucleotides with Imidazophenazine Dye and its Effect on Duplex Stability

  摘要：

  Carboxyalkyl derivative of the intercalating agent imidazo[4,5-b]phenazine was used for the postsynthetic oligonucleotide modification. Model pentadecathymidylate-imidazophenazine conjugate was prepared from 5'-aminoalkyl-modified (dT)(15) by using phosphonium coupling reagent BOP in the presence of 1-hydroxybenzotriazole. Spectral-fluorescent properties of the conjugate were studied. The attachment of the dye was found to increase the thermal stability of (dT)(15) duplex with poly(dA) by more than 4 degrees C, probably by the intercalation mechanism.

  DOI：

  10.1080/15257770.2011.598489
• 作为产物：
  描述：

  1H-imidazo[4,5-b]phenazine 、 3-溴丙酸乙酯 在 potassium carbonate 、 potassium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 以83%的产率得到ethyl 3-(N1-imidazo[4,5-b]phenazinyl)propionate
  参考文献：
  名称：

  Postsynthetic Modification of Oligonucleotides with Imidazophenazine Dye and its Effect on Duplex Stability

  摘要：

  Carboxyalkyl derivative of the intercalating agent imidazo[4,5-b]phenazine was used for the postsynthetic oligonucleotide modification. Model pentadecathymidylate-imidazophenazine conjugate was prepared from 5'-aminoalkyl-modified (dT)(15) by using phosphonium coupling reagent BOP in the presence of 1-hydroxybenzotriazole. Spectral-fluorescent properties of the conjugate were studied. The attachment of the dye was found to increase the thermal stability of (dT)(15) duplex with poly(dA) by more than 4 degrees C, probably by the intercalation mechanism.

  DOI：

  10.1080/15257770.2011.598489