2-chloro-5-trifluoromethylphenylacetylenyltrimethylsilane | 875558-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-5-trifluoromethylphenylacetylenyltrimethylsilane
• 英文别名: {[2-chloro-5-(trifluoromethyl)phenyl]ethynyl}(trimethyl)silane；{[2-Chloro-5-(trifluoromethyl)phenyl]ethynyl}(trimethyl)silane；2-[2-chloro-5-(trifluoromethyl)phenyl]ethynyl-trimethylsilane
• CAS: 875558-46-6
• 化学式: C₁₂H₁₂ClF₃Si
• 分子量: 276.761
• InChiKey: HUJUDGFSACTUBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.59
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-chloro-5-trifluoromethylphenylacetylenyltrimethylsilane 在 甲醇 、 正丁基锂 、 potassium carbonate 作用下， 生成 3-Hydroxy-3-trifluoromethyl-1-(2-chloro-5-trifluoromethylphenyl)-4,4,4-trifluorobut-1-yne
  参考文献：
  名称：

  The synthesis of 2,2-bis(trifluoromethyl)benzopyran derivatives: A new route to an important class of potassium channel activators

  摘要：

  A new route to an important class of biologically active benzopyrans was developed via an intramolecular cyclisation and cis diol formation.

  DOI：

  10.1016/s0040-4039(00)60787-6
• 作为产物：
  描述：

  3-溴-4-氯三氟甲苯 、 三甲基乙炔基硅 在 copper(l) iodide 、 四(三苯基膦)钯 三乙胺 作用下， 生成 2-chloro-5-trifluoromethylphenylacetylenyltrimethylsilane
  参考文献：
  名称：

  The synthesis of 2,2-bis(trifluoromethyl)benzopyran derivatives: A new route to an important class of potassium channel activators

  摘要：

  A new route to an important class of biologically active benzopyrans was developed via an intramolecular cyclisation and cis diol formation.

  DOI：

  10.1016/s0040-4039(00)60787-6

文献信息

• Substituted Pyrazoles, Compositions Containing such Compounds and Methods of Use
  申请人：Brockunier Linda

  公开号：US20080108620A1

  公开（公告）日：2008-05-08

  The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

  本发明涉及取代吡唑，含有此类化合物的组合物以及治疗方法。这些化合物是胰高血糖素受体拮抗剂，因此可用于治疗、预防或延迟2型糖尿病的发生。
• Substituted pyrazoles, compositions containing such compounds and methods of use
  申请人：Merck & Co., Inc.

  公开号：US07625938B2

  公开（公告）日：2009-12-01

  The present invention relates to substituted pyrazoles, compositions containing such compounds and methods of treatment. The compounds are glucagon receptor antagonists and thus are useful for treating, preventing or delaying the onset of type 2 diabetes mellitus.

  本发明涉及取代的吡唑，包含这种化合物的组合物和治疗方法。这些化合物是胰高血糖素受体拮抗剂，因此可用于治疗、预防或延缓2型糖尿病的发生。
• A Domino Protocol toward High‐performance Unsymmetrical Dibenzo[<i>d,d′</i>]thieno[2,3‐<i>b</i>;4,5‐<i>b</i>′]dithiophenes Semiconductors
  作者：Jiahui Li、Pu Wang、Jiaxuan Dong、Ziyi Xie、Xiangyu Tan、Lu Zhou、Liankun Ai、Baolin Li、Yang Wang、Huanli Dong

  DOI：10.1002/anie.202400803

  日期：2024.4.15

  A trisulfur radical anion (S3.−) triggered domino thienannulation strategy for the synthesis of dibenzo[d,d′]thieno[2,3-b;4,5-b′]dithiophenes (DBTDTs) has been developed. This domino protocol is featured by no metal catalyst and the formation of six C−S and one C−C bonds in one-pot reaction. A plausible mechanism has been proposed by control experiments, intermediate trapping experiments, etc. The

  开发了一种三硫自由基阴离子（S 3 .− ）触发的多米诺噻吩环化策略，用于合成二苯并[ d,d' ]噻吩并[2,3- b ;4,5- b ']二噻吩（DBTDT）。该多米诺骨牌协议的特点是无需金属催化剂，在一锅反应中形成六个 C−S 和一个 C−C 键。通过控制实验、中间捕获实验等提出了一种合理的机制。DBTDT独特的不对称结构赋予其人字形堆积结构和分子间弱的S⋅⋅⋅S相互作用以及高转移积分，从而实现高载流子有机场效应晶体管的迁移率为1.52 cm 2 V -1 s -1 。
• [EN] SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE<br/>[FR] PYRAZOLES SUBSTITUES, COMPOSITIONS CONTENANT DE TELS COMPOSES ET LEURS METHODES D'UTILISATION
  申请人：MERCK & CO INC

  公开号：WO2006014618A3

  公开（公告）日：2006-10-19
• The synthesis of 2,2-bis(trifluoromethyl)benzopyran derivatives: A new route to an important class of potassium channel activators
  作者：Ashley E Fenwick

  DOI：10.1016/s0040-4039(00)60787-6

  日期：1993.3

  A new route to an important class of biologically active benzopyrans was developed via an intramolecular cyclisation and cis diol formation.