8-Mercapto-9-methylpurine | 74537-62-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-Mercapto-9-methylpurine
• 英文别名: 9-methylpurine-8(7H)-thione；9-methyl-9H-purine-8-thiol；8-Mercapto-9-methylpurin；9-methyl-7,9-dihydro-purine-8-thione；9-methyl-7H-purine-8-thione
• CAS: 74537-62-5
• 化学式: C₆H₆N₄S
• 分子量: 166.206
• InChiKey: LOCQWLOWPUZSDX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  73.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-Mercapto-9-methylpurine 在 一水合肼 作用下， 以 正丁醇 为溶剂， 反应 18.0h， 以52%的产率得到9-methylpurin-8-ylhydrazine
  参考文献：
  名称：

  Brown, Desmond J.; Shinozuka, Kazuo, Australian Journal of Chemistry, 1982, vol. 35, # 6, p. 1263 - 1267

  摘要：

  DOI：
• 作为产物：
  描述：

  8-(methylthio)-9-methylpurine 在 氨 、 sodium 作用下， 反应 0.08h， 以100%的产率得到8-Mercapto-9-methylpurine
  参考文献：
  名称：

  Deamination of 6-amino- and 6-(alkylamino)-9-alkylpurines and demethylation of methylthiopurines by sodium in liquid ammonia

  摘要：

  DOI：

  10.1021/jo00337a037

文献信息

• Hindered disulfide drug conjugates
  申请人：Genentech, Inc.

  公开号：US10729738B2

  公开（公告）日：2020-08-04

  The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.

  本发明一般涉及二硫化物药物共轭物，其中由至少一个烃基或取代烃基取代的含硫碳原子组成的连接体通过二硫键与靶向载体的半胱氨酸硫原子共轭，并且连接体进一步与药物分子共轭。 本发明进一步涉及适合通过二硫键与靶向载体共轭的活化连接体-药物共轭物。 本发明进一步涉及制备受阻二硫化物药物共轭物的方法。
• 136. Purine studies. Part III. The structure of the monohydroxy- and monomercapto-purines : some thiazole[5 : 4-d]pyrimidines
  作者：D. J. Brown、S. F. Mason

  DOI：10.1039/jr9570000682

  日期：——
• BROWN, D. J.;SHINOZUKA, KAZUO, AUSTRAL. J. CHEM., 1982, 35, N 6, 1263-1267
  作者：BROWN, D. J.、SHINOZUKA, KAZUO

  DOI：——

  日期：——
• HINDERED DISULFIDE DRUG CONJUGATES
  申请人：Genentech, Inc.

  公开号：US20170112891A1

  公开（公告）日：2017-04-27

  The invention relates generally to disulfide drug conjugates wherein a linker comprising a sulfur-bearing carbon atom substituted with at least one hydrocarbyl or substituted hydrocarbyl is conjugated by a disulfide bond to a cysteine sulfur atom of a targeting carrier, and wherein the linker is further conjugated to a drug moiety. The invention further relates to activated linker-drug conjugates suitable for conjugation to a targeting carrier by a disulfide bond. The invention further relates to methods for preparing hindered disulfide drug conjugates.
• [EN] SMALL MOLECULE INHIBITORS OF HISTONE DEACTEYLASES<br/>[FR] INHIBITEURS À PETITE MOLÉCULE D'HISTONE DÉSACÉTYLASES
  申请人：NUPOTENTIAL INC

  公开号：WO2013059582A2

  公开（公告）日：2013-04-25

  The disclosure relates to small molecules and methods, compositions, and kits comprising these small molecules. In still another embodiment, the disclosure relates to small molecules that inhibit HDAC activity. In yet another embodiment, the disclosure relates to small molecules for inhibiting the growth of cancer cells. In still another embodiment, the disclosure relates to small molecules for reprogramming a cell.