N-(3-氨基丙基)-N'-甲基丙烷-1,3-二胺 | 16968-18-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(3-氨基丙基)-N'-甲基丙烷-1,3-二胺
• 英文名称: 4,8-Diazanonamin
• 英文别名: N-(3-aminopropyl)-N'-methylpropane-1,3-diamine；N'-[3-(methylamino)propyl]propane-1,3-diamine
• CAS: 16968-18-6
• 化学式: C₇H₁₉N₃
• mdl: MFCD19205222
• 分子量: 145.248
• InChiKey: RUFPEZGNIWGNQW-UHFFFAOYSA-N

物化性质

• 沸点：
  240.0±8.0 °C(Predicted)
• 密度：
  0.878±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  10
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  50.1
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 海关编码：
  2921290000

反应信息

• 作为反应物：
  描述：

  N-(3-氨基丙基)-N'-甲基丙烷-1,3-二胺 、 1,5-二环己基-3-戊酮 生成 [3-(3-Amino-propylamino)-propyl]-[3-cyclohexyl-1-(2-cyclohexyl-ethyl)-propyl]-methyl-amine
  参考文献：
  名称：

  Antibacterial N-[.omega.,.omega.'-bis(alicyclic and aryl)-sec-alkyl]poly(methylenetriamine and -tetramine) hydrochloride salts

  摘要：

  A series of antibacterial N-(omega, omega'-(cycloalkyl, bicyclo[2.2.1]heptyl, and alkyl-substituted phenyl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitors, particularly for Pseudomonas aeruginosa. In the 1,5,9-triazanonane group, 3 of 16 compounds were effective at 8--10 micrograms/mL against pseudomonads. Efficiency appeared more dependent upon lipophilicity of the nitrogen substituent than other characteristics represented by the three types of rings. A parabolic relationship was observed for the entire set between the hydrophobic parameter, pi, of the lipoidal moiety and minimal inhibitory concentration. One of 16 tetramines, 1-[1,5-bis(3,3-dimethyl-2-norbornyl)-3-pentyl]-1,5,9,13-tetraazatridecane tetrahydrochloride (26f), ranked similarly. An additional two compounds in each series were superior to several commercial cationic detergents in the control of the Gram-negative bacteria. None was inhibitory at up to 200 micrograms/mL for Proteus vulgaris.

  DOI：

  10.1021/jm00197a024

文献信息

• [EN] METHODS TO PRODUCE ALKYLATED POLYCYCLIC GUANIDINE COMPOUNDS<br/>[FR] PROCÉDÉS DE FABRICATION DE COMPOSÉS GUANIDINES POLYCYCLIQUES ALKYLÉES
  申请人：NOVOMER INC

  公开号：WO2013055747A1

  公开（公告）日：2013-04-18

  The present invention encompasses methods of synthesizing N-alkyl derivatives of polycyclic guanidines having an exchangeable NH group by reaction with dialkylcarbonates. In one aspect, the invention provides a method to make methyl TBD (1- Methyl- 1, 4, 9-Triazabicyclof 4.4.0] dec-9-ene) by heating a mixture of TBD and dimethyl carbonate.

  本发明涵盖了通过与二烷基碳酸酯反应合成具有可交换NH基团的多环胍基N-烷基衍生物的方法。在一个方面，本发明提供了一种通过加热TBD和二甲基碳酸酯的混合物制备甲基TBD（1-甲基-1,4,9-三氮杂双环[4.4.0]庚-9-烯）的方法。
• [EN] LIPOCATIONIC DENDRIMERS AND USES THEREOF<br/>[FR] DENDRIMÈRES LIPOCATIONIQUES ET LEURS UTILISATIONS
  申请人：UNIV TEXAS

  公开号：WO2017048789A1

  公开（公告）日：2017-03-23

  Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid.

  本文提供了带有阳离子基团和亲脂基团的模块化树状聚合物。在某些方面，本文提供的树状聚合物可以配制成含有核酸和一个或多个辅助赋形剂的组合物。在某些方面，这些组合物也可以用于治疗含有治疗性核酸的疾病或疾患。
• DERIVATIVES OF XANTHONE COMPOUNDS
  申请人：Zou Hanxun

  公开号：US20140349918A1

  公开（公告）日：2014-11-27

  The present invention relates to xanthone analogs. Such compounds may be used in the treatment of bacterial infections.

  本发明涉及黄酮类似物。这些化合物可用于治疗细菌感染。
• AMIDE DERIVATIVES OF SQUALAMINE FOR THE TREATMENT OF INFECTIONS
  申请人：VIRBAC

  公开号：US20190262362A1

  公开（公告）日：2019-08-29

  A compound of formula (I) in which R′ represents a group —(CR a R b ) n —X—(CR c R d ) m —[Y—(CR e R f ) o ] t —NR 9 R 10 and X and Y independently represent a group —NR11-, a group —O— or a divalent 5-membered or 6-membered heterocyclic group comprising at least one nitrogen atom, and also the stereoisomers, mixtures of stereoisomers, and/or pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical or veterinary compositions containing the compound of formula (I) and also to the use thereof as medicament, more particularly in the treatment of bacterial, fungal, viral or parasitic infections. Also further disclosed are pharmaceutical or veterinary compositions including the compound of formula (I) in combination with an antibiotic other than such a compound of formula (I).

  化合物的公式(I)，其中R′代表一个基团- (CRaRb)n-X-(CRcRd)m-[Y-(CReRf)o]t-NR9R10，X和Y分别代表一个基团-NR11-，一个基团-O-或者至少包含一个氮原子的二价五元或六元杂环基团，以及其立体异构体、立体异构体混合物和/或药学上可接受的盐。还公开了包含公式(I)化合物的制药或兽医组合物，以及在治疗细菌、真菌、病毒或寄生虫感染方面作为药物的用途。还公开了包含公式(I)化合物和除公式(I)化合物以外的抗生素的制药或兽医组合物。
• Method of Making an Artificial Nuclease for Anti-viral, Anti-bacterial Applications
  申请人：Chang Eddie

  公开号：US20080319181A1

  公开（公告）日：2008-12-25

  A method of making a macrocyclic chelator comprising converting Co(II)Cl 2 to a stabilized Co(III) complex, reacting the Co(III) complex with a cyclen ligand comprising a carboxylic acid or a methyl benzoic acid moiety through which amine bond formation with a primary amine can be achieved and reacting the Co(III) cyclen carboxylic acid or methyl benzoic acid complex with a suitable modified oligonucleotide to form a sequence-specific gene silencing moiety. A method comprising coordinating a kinetically inert ion to a macrocyclic chelator or ligand, bonding a first functional group, reacting with an oligonucleotide, bonding a second functional group, attaching the first functional group to the second functional group, binding the macrocyclic chelator to a target thus inhibiting translation, wherein the macrocyclic chelator hydrolyzes a photodiester bond.

  一种制备大环螯合剂的方法，包括将Co(II)Cl2转化为稳定的Co(III)配合物，将Co(III)配合物与含有羧酸或甲基苯甲酸基团的cyclen配体反应，通过其中的一个基团与一级胺形成胺键，然后将Co(III) cyclen羧酸或甲基苯甲酸配合物与适当的修饰寡核苷酸反应，形成序列特异性基因沉默的结构单元。一种方法包括将一个动力学惰性离子配位到大环螯合剂或配体上，结合第一个功能基团，反应寡核苷酸，结合第二个功能基团，将第一个功能基团连接到第二个功能基团，将大环螯合剂与靶结合，从而抑制翻译作用，其中大环螯合剂水解光二酯键。