1-acetylamino-2-phenylcarbamoyloxy-benzene | 21567-06-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-acetylamino-2-phenylcarbamoyloxy-benzene
• 英文别名: (2-Acetamino-phenyl)-kohlensaeure-anilid；Phenylcarbamidsaeure-(2-acetamino-phenyl)-ester；1-Acetylamino-2-phenylcarbamoyloxy-benzol；(2-acetamidophenyl) N-phenylcarbamate
• CAS: 21567-06-6
• 化学式: C₁₅H₁₄N₂O₃
• 分子量: 270.288
• InChiKey: RSENSIITZOYUAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异氰酸苯酯 、 邻乙酰氨基酚 在 甲苯 作用下， 生成 1-acetylamino-2-phenylcarbamoyloxy-benzene
  参考文献：
  名称：

  EFFICACY, SAFETY AND PATIENT SATISFACTION OUTCOMES OF THE AMS 700CX INFLATABLE PENILE PROSTHESIS: RESULTS OF A LONG-TERM MULTICENTER STUDY

  摘要：

  Purpose: We performed a long-term multicenter study of the AMS 700CX double dagger 3-piece inflatable penile prosthesis, focusing on longevity, morbidity and patient satisfaction in men implanted up to 134 months with a median followup of 47.7 months.Materials and Methods: We performed a large scale retrospective multicenter study in 2 phases. Phase 1 was a medical record review of 372 men who underwent implantation with the AMS 700CX penile prosthesis from 1987 to 1996 by 7 frequent penile prosthesis implanters, Phase 2 included a structured telephone interview of 207 patients by a neutral observer.Results: For the 372 men in phase 1 mean device mechanical reliability plus or minus standard deviation was 92.1% +/- 3.3% affer 3 and 86.2% +/- 4.6% after 5 years. Patient age was 21 to 79 years (mean 57.6 +/- 11.0) at implantation. The etiology of erectile dysfunction was vascular in 27.7% of the cases, Peyronie's disease in 16.9%, diabetes mellitus in 12.9% and radical surgery in 11.6%. Of the men 55.6% received previous treatment for erectile dysfunction. Postoperative infection and device malfunction developed in 3.2% and 17.5% of the cases, respectively. Of the 207 men interviewed in phase 2, 86% still had an AMS 700CX penile prosthesis implanted, including 87.1% with erection suitable for coitus. Currently 79% of those with a device use it at least twice monthly and 88.2% would recommend an implant to a relative or friend.Conclusions: The AMS 700CX penile implant produced suitable erection and excellent patient satisfaction at long-term followup in the majority of men. Implant reliability is excellent and postoperative morbidity is low.

  DOI：

  10.1016/s0022-5347(05)67364-8

文献信息

• EFFICACY, SAFETY AND PATIENT SATISFACTION OUTCOMES OF THE AMS 700CX INFLATABLE PENILE PROSTHESIS: RESULTS OF A LONG-TERM MULTICENTER STUDY
  作者：CULLEY C. CARSON、JOHN J. MULCAHY、FRED E. GOVIER

  DOI：10.1016/s0022-5347(05)67364-8

  日期：2000.8

  Purpose: We performed a long-term multicenter study of the AMS 700CX double dagger 3-piece inflatable penile prosthesis, focusing on longevity, morbidity and patient satisfaction in men implanted up to 134 months with a median followup of 47.7 months.Materials and Methods: We performed a large scale retrospective multicenter study in 2 phases. Phase 1 was a medical record review of 372 men who underwent implantation with the AMS 700CX penile prosthesis from 1987 to 1996 by 7 frequent penile prosthesis implanters, Phase 2 included a structured telephone interview of 207 patients by a neutral observer.Results: For the 372 men in phase 1 mean device mechanical reliability plus or minus standard deviation was 92.1% +/- 3.3% affer 3 and 86.2% +/- 4.6% after 5 years. Patient age was 21 to 79 years (mean 57.6 +/- 11.0) at implantation. The etiology of erectile dysfunction was vascular in 27.7% of the cases, Peyronie's disease in 16.9%, diabetes mellitus in 12.9% and radical surgery in 11.6%. Of the men 55.6% received previous treatment for erectile dysfunction. Postoperative infection and device malfunction developed in 3.2% and 17.5% of the cases, respectively. Of the 207 men interviewed in phase 2, 86% still had an AMS 700CX penile prosthesis implanted, including 87.1% with erection suitable for coitus. Currently 79% of those with a device use it at least twice monthly and 88.2% would recommend an implant to a relative or friend.Conclusions: The AMS 700CX penile implant produced suitable erection and excellent patient satisfaction at long-term followup in the majority of men. Implant reliability is excellent and postoperative morbidity is low.