2-[2-(4-Trifluoromethyl-phenyl)-ethoxy]-tetrahydro-pyran | 502699-25-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[2-(4-Trifluoromethyl-phenyl)-ethoxy]-tetrahydro-pyran
• 英文别名: 2-[2-[4-(Trifluoromethyl)phenyl]ethoxy]oxane
• CAS: 502699-25-4
• 化学式: C₁₄H₁₇F₃O₂
• 分子量: 274.283
• InChiKey: AJEFAHVJPKKVLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2-(4-Trifluoromethyl-phenyl)-ethoxy]-tetrahydro-pyran 在 indium(III) triflate 作用下， 以 甲醇 、 水 为溶剂， 反应 6.0h， 以85%的产率得到4-(三氟甲基)苯乙醇
  参考文献：
  名称：

  A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

  摘要：

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01864-6
• 作为产物：
  描述：

  3,4-二氢-2H-吡喃 、 4-(三氟甲基)苯乙醇 在 indium(III) triflate 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以80%的产率得到2-[2-(4-Trifluoromethyl-phenyl)-ethoxy]-tetrahydro-pyran
  参考文献：
  名称：

  A fast and practical approach to tetrahydropyranylation and depyranylation of alcohols using indium triflate

  摘要：

  Indium triflate-mediated tetrahydropyranylation of alcohols in dichloromethane and depyranylation of these products in aqueous methanol utilizing the same reagent but different molar ratio is described. In addition, indium triflate-promoted conversion of tetrahydropyran ethers to their corresponding acetates has also been described. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)01864-6