Bis[(2-aminoethyl)sulfanyl]-2H-1,3-dithiole-2-thione

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: Bis[(2-aminoethyl)sulfanyl]-2H-1,3-dithiole-2-thione
• 英文别名: 4,5-bis(2-aminoethylsulfanyl)-1,3-dithiole-2-thione
• 化学式: C₇H₁₂N₂S₅
• mdl: MFCD01142902
• 分子量: 284.516
• InChiKey: BLYODLNRWWMGGM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  185
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  Bis[(2-aminoethyl)sulfanyl]-2H-1,3-dithiole-2-thione 、 3,4,5-trisdodecyloxybenzoic acid 2,5-dioxopyrrolidin-1-yl ester 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以5.54 g的产率得到N,N'-(((2-thioxo-1,3-dithiole-4,5-diyl)bis(sulfanediyl))bis(ethane-2,1-diyl))bis(3,4,5-tris(dodecyloxy)benzamide)
  参考文献：
  名称：

  毫米厚膜中盘状液晶分子大面积取向的电场响应手柄

  摘要：

  时事：开发了一种电场响应手柄（参见图片），该手柄能够使大面积和毫米厚度的圆柱状组装的π共轭液晶分子单向定向。列中的手柄是氢键的，并沿着施加的电场方向对齐。

  DOI：

  10.1002/anie.201102472
• 作为产物：
  描述：

  在 三氟乙酸 作用下， 反应 1.08h， 生成 Bis[(2-aminoethyl)sulfanyl]-2H-1,3-dithiole-2-thione
  参考文献：
  名称：

  毫米厚膜中盘状液晶分子大面积取向的电场响应手柄

  摘要：

  时事：开发了一种电场响应手柄（参见图片），该手柄能够使大面积和毫米厚度的圆柱状组装的π共轭液晶分子单向定向。列中的手柄是氢键的，并沿着施加的电场方向对齐。

  DOI：

  10.1002/anie.201102472

文献信息

• IDO Inhibitors
  申请人：Mautino Mario

  公开号：US20110053941A1

  公开（公告）日：2011-03-03

  Presently provided are methods for (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (d) enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent and a compound as described in one of the aspects described herein; (e) treating tumor-specific immunosuppression associated with cancer comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; and (f) treating immunosuppression associated with an infectious disease, e.g., HIV-I infection, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount a compound as described in one of the aspects described herein.

  目前提供以下方法：(a) 通过接触本文中描述的化合物的调节有效量与吲哚胺2,3-二氧化酶相互作用，从而调节吲哚胺2,3-二氧化酶的活性；(b) 治疗需要吲哚胺2,3-二氧化酶(IDO)介导的免疫抑制的患者，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(c) 治疗需要抑制吲哚胺-2,3-二氧化酶酶活性的医疗状况，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(d) 增强抗癌治疗的有效性，包括给予抗癌剂和本文中描述的化合物；(e) 治疗与癌症相关的肿瘤特异性免疫抑制，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量；(f) 治疗与传染病相关的免疫抑制，例如HIV-1感染，包括给予本文中描述的化合物的有效吲哚胺2,3-二氧化酶抑制剂量。
• MULTISENSOR ARRAY FOR DETECTION OF ANALYTES OR MIXTURES THEREOF IN GAS OR LIQUID PHASE
  申请人：Jeppesen Jan Oskar

  公开号：US20130096030A1

  公开（公告）日：2013-04-18

  The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X 1 -X 4 and the substituents R 1 -R 4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.

  本发明涉及一种多传感器阵列，用于检测气相或液相中的分析物，包括至少两种不同的化学选择性化合物，由一般式（I）表示，其中杂原子X1-X4和取代基R1-R4在说明书中定义，虚线键独立地表示单键或双键。所述化学选择性化合物在暴露于分析物或分析物混合物时能够单独改变物理化学性质，这些变化可以被传感器或传感器阵列检测到。本发明还涉及在传感器阵列中使用至少两种不同的化学选择性化合物，制备这种传感器阵列的方法以及使用该传感器阵列的方法。此外，本发明还涉及检测和鉴定气相或液相中的分析物或混合物的方法。
• US9671392B2
  申请人：——

  公开号：US9671392B2

  公开（公告）日：2017-06-06
• [EN] MULTISENSOR ARRAY FOR DETECTION OF ANALYTES OR MIXTURES THEREOF IN GAS OR LIQUID PHASE<br/>[FR] RÉSEAU MULTICAPTEUR POUR LA DÉTECTION D'ANALYTES OU DE MÉLANGES DE CEUX-CI EN PHASE GAZEUSE OU LIQUIDE
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2011121077A1

  公开（公告）日：2011-10-06

  The present invention relates to a multisensor array for detection of analytes in the gas phase or in the liquid phase, comprising at least two different chemo-selective compounds represented by the general formula (I) wherein the hetero atoms X1-X4 and the substituents R1-R4 are defined in the specification and the dashed bonds represent independently of each other either a single bond or a double bond. Said chemo-selective compounds are capable of individually changing physicochemical properties when exposed to analytes or analyte mixtures and these changes can be detected by a transducer or an array of transducers. The present invention does also relate to the use of at least two different chemo-selective compounds in a sensor array, a method for preparation of such sensor arrays and the use of said sensor arrays. Furthermore the present invention relates to methods for detecting and identifying analytes or mixtures thereof in the gas phase or in the liquid phase.