3-bromo-4-methyl-2-oxo-2H,8H-pyrano[2,3-f]chromene-9-carbaldehyde | 1051922-06-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3-bromo-4-methyl-2-oxo-2H,8H-pyrano[2,3-f]chromene-9-carbaldehyde
• 英文别名: 3-bromo-4-methyl-2-oxo-8H-pyrano[2,3-f]chromene-9-carbaldehyde
• CAS: 1051922-06-5
• 化学式: C₁₄H₉BrO₄
• 分子量: 321.127
• InChiKey: GNJJUWUEHGZENR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-bromo-7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde 、 丙烯醛 在 三乙烯二胺 作用下， 以 氯仿 为溶剂， 反应 36.0h， 以74%的产率得到3-bromo-4-methyl-2-oxo-2H,8H-pyrano[2,3-f]chromene-9-carbaldehyde
  参考文献：
  名称：

  New Entry to 9-Acetyl/Formyl-Substituted 2H,8H-Pyrano[2,3-f]Chromen-2-ones through Baylis–Hillman Reaction

  摘要：

  A new facile route to 9-acetyl/formyl-substituted 2H,8H-pyrano[2,3-f]chromen-2-ones is described. The Baylis-Hillman reaction involving the condensation of methyl vinyl ketone/acrolein with 7-hydroxy-2-oxo-2H-chromen-8-carbaldehydes in the presence of diazabicyclo[2.2.2]octane (DABCO) under N-2 atmosphere at room temperature furnished the desired compounds in good yields.

  DOI：

  10.1080/00397910802139346

文献信息

• New Entry to 9-Acetyl/Formyl-Substituted 2<i>H</i>,8<i>H</i>-Pyrano[2,3-<i>f</i>]Chromen-2-ones through Baylis–Hillman Reaction
  作者：A. Raghotham、T. Lavanya、P. Pratap Reddy

  DOI：10.1080/00397910802139346

  日期：2008.6.27

  A new facile route to 9-acetyl/formyl-substituted 2H,8H-pyrano[2,3-f]chromen-2-ones is described. The Baylis-Hillman reaction involving the condensation of methyl vinyl ketone/acrolein with 7-hydroxy-2-oxo-2H-chromen-8-carbaldehydes in the presence of diazabicyclo[2.2.2]octane (DABCO) under N-2 atmosphere at room temperature furnished the desired compounds in good yields.