3-benzoylamino-benzoic acid amide | 306325-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-benzoylamino-benzoic acid amide
• 英文别名: 3-Benzoylamino-benzoesaeure-amid；3-Benzamino-benzamid；3-Benzamidobenzamide
• CAS: 306325-17-7
• 化学式: C₁₄H₁₂N₂O₂
• mdl: MFCD00812659
• 分子量: 240.261
• InChiKey: KXRBIKHMBTVXSC-UHFFFAOYSA-N

物化性质

• 熔点：
  233 °C
• 沸点：
  353.0±25.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-benzoylamino-benzoic acid amide 、 三氯乙醛 生成 3-benzoylamino-benzoic acid-(2,2,2-trichloro-1-hydroxy-ethylamide)
  参考文献：
  名称：

  Hirwe; Kulkarni, Proceedings - Indian Academy of Sciences, Section A, 1941, vol. 13, p. 50

  摘要：

  DOI：
• 作为产物：
  描述：

  3-硝基苯甲酰胺 在 sodium sulfide 、 乙醇 、 sulfur 作用下， 生成 3-benzoylamino-benzoic acid amide
  参考文献：
  名称：

  Blanksma; Petri, Recueil des Travaux Chimiques des Pays-Bas, 1947, vol. 66, p. 369

  摘要：

  DOI：

文献信息

• Compounds and Compositions as Protein Kinase Inhibitors
  申请人：Wan Yongqin

  公开号：US20080221192A1

  公开（公告）日：2008-09-11

  The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-Abl, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC kinases.

  本发明提供了一类新型化合物，包括该类化合物的药物组合物以及使用该类化合物治疗或预防与异常或失调激酶活性相关的疾病或障碍的方法，特别是涉及Abl、Bcr-Abl、cSrc、TPR-Met、Tie2、MET、FGFR3、Aurora、Axl、Bmx、BTK、c-kit、CHK2、Flt3、MST2、p70S6K、PDGFR、PKB、PKC、Raf、ROCK-H、Rsk1、SGK、TrkA、TrkB和TrkC激酶异常活化的疾病或障碍。
• AMIDE DERIVATIVES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS INSECTICIDE
  申请人：MITSUI CHEMICALS, INC.

  公开号：US20140206727A1

  公开（公告）日：2014-07-24

  A compound represented by Formula (1): The compound can be used as insecticides.

  由公式（1）表示的化合物：该化合物可用作杀虫剂。
• AMIDE DERIVATIVES, PROCESS FOR PRODUCTION OF THE SAME, AND METHOD FOR APPLICATION THEREOF AS INSECTICIDE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1714958A1

  公开（公告）日：2006-10-25

  An object of the present invention is to provide a compound represented by Formula (1): wherein A1, A2, A3 and A4 each represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; R1 and R2 each represent a hydrogen atom, an optionally substituted alkyl group or an optionally substituted C1-C4 alkylcarbonyl group; G1 and G2 each represent an oxygen atom or a sulfur atom; X, which may be identical or different each other, represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a trifluoromethyl group; n is an integer of 0 to 4; and Q1 represents an optionally substituted phenyl group, an optionally substituted naphthyl group or an optionally substituted heterocyclic group; Q2 represents a phenyl group or heterocyclic group having one or more substituents, at least one of the substituent being any of a C1-C4 haloalkoxy group, a C2-C6 perfluoroalkyl group, a C1-C6 perfluoroalkylthio group, a C1-C6 perfluoroalkylsulfinyl group and a C1-C6 perfluoroalkylsulfonyl group, an insecticide comprising the compound as the active ingredient, and a process for preparation thereof.

  本发明的目的是提供一种由式（1）表示的化合物： 其中 A1、A2、A3 和 A4 各自代表碳原子、氮原子或氧化氮原子； R1 和 R2 各自代表氢原子、任选取代的烷基或任选取代的 C1-C4 烷基羰基； G1 和 G2 分别代表氧原子或硫原子； X（可以相同或互不相同）代表氢原子、卤素原子、C1-C3 烷基或三氟甲基； n 是 0 至 4 的整数；以及 Q1 代表任选取代的苯基、任选取代的萘基或任选取代的杂环基团； Q2 代表具有一个或多个取代基的苯基或杂环基团，其中至少一个取代基为 C1-C4 卤代烷氧基、C2-C6 全氟烷基、C1-C6 全氟烷硫基、C1-C6 全氟烷基亚磺酰基和 C1-C6 全氟烷基磺酰基中的任一基团、 以该化合物为活性成分的杀虫剂及其制备方法。
• PEST CONTROL COMPOSITION
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1913815A1

  公开（公告）日：2008-04-23

  There is a harmful organism that cannot be controlled or is difficult to be controlled with the use of a single agent of a compound represented by the general formula (1) according to the invention, an insecticide, a miticide or a bactericide. Accordingly, an object of the invention is to provide a composition for preventing harmful organisms for efficiently controlling such a harmful organism. That is, the invention is directed to a composition for preventing harmful organisms, characterized by comprising the compound represented by the general formula (1) and other insecticides, miticides or bactericides as active ingredients, wherein, in the formula, A1, A2, A3 and A4 independently represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; G1 and G2 independently represent an oxygen atom or a sulfur atom; R1 and R2 independently represent a hydrogen atom or a C1 to C4 alkyl group; Xs may be the same or different and represent a hydrogen atom, a halogen atom or a trifluoromethyl group; Q1 represents a substituent such as a phenyl group or a heterocyclic group; and Q2 represents a substituent such as a phenyl group or a heterocyclic group.)

  有一种有害生物，使用本发明通式(1)代表的化合物、杀虫剂、杀螨剂或杀菌剂的单剂无法控制或难以控制。因此，本发明的目的是提供一种预防有害生物的组合物，以有效地控制这种有害生物。 也就是说，本发明涉及一种用于预防有害生物的组合物，其特征在于包含通式（1）所代表的化合物和其他杀虫剂、杀螨剂或杀菌剂作为活性成分、 其中，在式中，A1、A2、A3和A4独立地代表碳原子、氮原子或氧化氮原子；G1和G2独立地代表氧原子或硫原子；R1和R2独立地代表氢原子或C1至C4烷基；Xs可以相同或不同，代表氢原子、卤素原子或三氟甲基；Q1代表取代基，如苯基或杂环基；Q2代表取代基，如苯基或杂环基)。
• Amide derivatives, process for preparation thereof and use thereof as insecticide
  申请人：MITSUI CHEMICALS, INC.

  公开号：US10435385B2

  公开（公告）日：2019-10-08

  A compound represented by Formula (1): The compound can be used as insecticides.

  式 (1) 所代表的化合物： 该化合物可用作杀虫剂。