N-(4-amino-2-chlorophenyl)-2,2,2-trifluoroacetamide | 766519-21-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-amino-2-chlorophenyl)-2,2,2-trifluoroacetamide
• CAS: 766519-21-5
• 化学式: C₈H₆ClF₃N₂O
• 分子量: 238.597
• InChiKey: ZXCOYCIWERPDIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-(4-amino-2-chlorophenyl)-2,2,2-trifluoroacetamide 在 TEA 、 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 N-(4-amino-3-chloro-phenyl)-2-fluoro-benzamide
  参考文献：
  名称：

  Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus

  摘要：

  The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC(50)s < 0.1 muM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.025
• 作为产物：
  描述：

  2-氯-4-硝基苯胺 生成 N-(4-amino-2-chlorophenyl)-2,2,2-trifluoroacetamide
  参考文献：
  名称：

  Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus

  摘要：

  The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC(50)s < 0.1 muM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.025

文献信息

• [EN] SUBSTITUTED P-DIAMINOBENZENE DERIVATIVES<br/>[FR] DERIVES DE PARA-DIAMINOBENZENE SUBSTITUES
  申请人：LUNDBECK & CO AS H

  公开号：WO2004082677A1

  公开（公告）日：2004-09-30

  The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

  本发明涉及通式I的苯胺衍生物或其药学上可接受的盐及其用途。
• Substituted p-diaminobenzene derivatives
  申请人：Khanzhin Nikolay

  公开号：US20060183791A1

  公开（公告）日：2006-08-17

  The present invention relates to aniline derivatives of the general formula I or pharmaceutically acceptable salts thereof and their use.

  本发明涉及一般式I的苯胺衍生物或其药学上可接受的盐及其用途。
• EP1613303A1
  申请人：——

  公开号：EP1613303A1

  公开（公告）日：2006-01-11
• US7906537B2
  申请人：——

  公开号：US7906537B2

  公开（公告）日：2011-03-15
• Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus
  作者：Martin J Di Grandi、Kevin J Curran、Gregg Feigelson、Amar Prashad、Adma A Ross、Robert Visalli、Jeanette Fairhurst、Boris Feld、Jonathan D Bloom

  DOI：10.1016/j.bmcl.2004.06.025

  日期：2004.8

  The preparation of alpha-methylbenzyl thioureas and their biological activity against varicella zoster virus is described. Several analogs demonstrated IC(50)s < 0.1 muM and their SAR are discussed. These compounds represent a novel class of potent and selective nonnucleoside inhibitors of varicella zoster virus. (C) 2004 Elsevier Ltd. All rights reserved.