2-methyl-3-linoleyloxy-7-carboxymethylthio-pyrazolo[4,3-d]pyrimidine | 107356-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 2-methyl-3-linoleyloxy-7-carboxymethylthio-pyrazolo[4,3-d]pyrimidine
• 英文别名: 2-[2-methyl-3-[(9Z,12Z)-octadeca-9,12-dienoxy]pyrazolo[4,3-d]pyrimidin-7-yl]sulfanylacetic acid
• CAS: 107356-46-7
• 化学式: C₂₆H₄₀N₄O₃S
• 分子量: 488.695
• InChiKey: BQZIWZYMSFWMKF-NQLNTKRDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  34
• 可旋转键数：
  19
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-methyl-3-linoleyloxy-7-carboxymethylthio-pyrazolo[4,3-d]pyrimidine 、 sodium carbonate 以 甲醇 为溶剂， 以2.41 g (94.5%)的产率得到Sodium salt of 2-methyl-3-linoleyloxy-7-carboxymethylthio-pyrazolo[4,3-d]pyrimidine
  参考文献：
  名称：

  Pyrazolo[4,3-d]pyrimidine derivative, process for its production, and

  摘要：

  一种具有以下式子的吡唑并[4,3-d]嘧啶衍生物：##STR1##其中R1为未取代或取代为低碳基，低烷氧基或卤素的苯基或低烷基；R2为饱和或不饱和的，直链或支链的脂肪族基，其有2到22个碳原子或苯基-低烷基，苯基未取代或取代为低碳基，低烷氧基或卤素；A为具有1至3个碳原子的烷基，未取代或取代为甲基，或其药学上可接受的盐。

  公开号：

  US04746663A1

文献信息

• Pyrazolo [4,3-d] pyrimidine derivative, process for its production, and antihyperlipidemic or antiatheroschlerotic agent containing it
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0210653A2

  公开（公告）日：1987-02-04

  A pyrazolo[4,3-d]pyrimidine derivative having the formula: wherein R' is lower alkyl or phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; R2 is a saturated or unsaturated, straight chain or branched aliphatic group having from 2 to 22 carbon atoms or phenyl-lower alkyl with the phenyl group unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; and A is an alkylene group having from 1 to 3 carbon atoms which is unsubstituted or substituted by methyl, or a pharmaceutically acceptable salt thereof

  一种吡唑并[4,3-d]嘧啶衍生物，其式如下 其中 R' 是低级烷基或未被低级烷基、低级烷氧基或卤素取代或取代的苯基；R2 是具有 2 至 22 个碳原子的饱和或不饱和、直链或支链脂肪族基团或苯基-低级烷基，其中苯基未被低级烷基、低级烷氧基或卤素取代或取代；以及 A 是具有 1 至 3 个碳原子的未被甲基取代或取代的亚烷基，或其药学上可接受的盐
• US4746663A
  申请人：——

  公开号：US4746663A

  公开（公告）日：1988-05-24
• Pyrazolo[4,3-d]pyrimidine derivative, process for its production, and
  申请人：Nissan Chemical Industries Ltd.

  公开号：US04746663A1

  公开（公告）日：1988-05-24

  A pyrazolo[4,3-d]pyrimidine derivative having the formula: ##STR1## wherein R.sup.1 is lower alkyl or phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; R.sup.2 is a saturated or unsaturated, straight chain or branched aliphatic group having from 2 to 22 carbon atoms or phenyl-lower alkyl with the phenyl group unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; and A is an alkylene group having from 1 to 3 carbon atoms which is unsubstituted or substituted by methyl, or a pharmaceutically acceptable salt thereof.

  一种具有以下式子的吡唑并[4,3-d]嘧啶衍生物：##STR1##其中R1为未取代或取代为低碳基，低烷氧基或卤素的苯基或低烷基；R2为饱和或不饱和的，直链或支链的脂肪族基，其有2到22个碳原子或苯基-低烷基，苯基未取代或取代为低碳基，低烷氧基或卤素；A为具有1至3个碳原子的烷基，未取代或取代为甲基，或其药学上可接受的盐。