2-Methyl-3-linoleyloxy-7-methoxycarbonylmethylthio-pyrazolo[4,3-d]pyrimidine | 107356-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 2-Methyl-3-linoleyloxy-7-methoxycarbonylmethylthio-pyrazolo[4,3-d]pyrimidine
• 英文别名: methyl 2-[2-methyl-3-[(9Z,12Z)-octadeca-9,12-dienoxy]pyrazolo[4,3-d]pyrimidin-7-yl]sulfanylacetate
• CAS: 107356-50-3
• 化学式: C₂₇H₄₂N₄O₃S
• 分子量: 502.721
• InChiKey: FWFMQOJFSDLSAX-MURFETPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.2
• 重原子数：
  35
• 可旋转键数：
  20
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-methyl-3-hydroxy-7-methoxycarbonylmethylthio-pyrazolo[4,3-d]pyrimidine 生成 2-Methyl-3-linoleyloxy-7-methoxycarbonylmethylthio-pyrazolo[4,3-d]pyrimidine
  参考文献：
  名称：

  FUJIKAWA, YOSHIHIRO;SUZUKI, MIKIO;SAKASHITA, MITSUAKI;TSURUZOE, NOBUTOMO;+

  摘要：

  DOI：

文献信息

• Pyrazolo[4,3-d] pyrimidine derivative process for its production antihyperlipidemic agent containing it, its intermediate, and process for the production of the intermediate
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0157415A2

  公开（公告）日：1985-10-09

  A pyrazolo[4,3-d]pyrimidine derivative having the formula: wherein R1 is lower alkyl, phenyl or substituted phenyl, R2 is -A-CO2R21 (wherein A is alkylene having from 1 to 3 carbon atoms which is unsubstituted or substituted by methyl, and R21 is lower alkyl having from 1 to 4 carbon atoms), -CH2CO-phenyl, a saturated or unsaturated, straight chain or branched aliphatic group having from 3 to 16 carbon atoms, phenyl-lower alkyl, -CH2CN, substituted phenyl-lower alkyl, cyclohexylcyclohexyl, methylcyclohexyl, 4-thia-n-heptyl, 3,6-dioxa-n-octyl, 4-oxo-n-pentyl or (wherein R22 is hydrogen or lower alkyl), and R3 is a saturated or unsaturated, straight chain or branched aliphatic group having from 2 to 22 carbon atoms, phenyl-lower alkyl, substituted phenyl-lower alkyl, substituted or unsubstituted phenyl-methyloxyethyl or 2-hydroxyethyl.

  一种吡唑并[4,3-d]嘧啶衍生物，其式如下 其中 R1 是低级烷基、苯基或取代苯基，R2 是-A-CO2R21（其中 A 是具有 1 至 3 个碳原子的亚烷基，未被取代或被甲基取代，R21 是具有 1 至 4 个碳原子的低级烷基），-CH2CO-苯基、具有 3 至 16 个碳原子的饱和或不饱和、直链或支链脂肪族基团、苯基低级烷基、-CH2CN、取代苯基低级烷基、环己基环己基、甲基环己基、4-硫杂-n-庚基、3,6-二氧杂-n-辛基、4-氧代-n-戊基，或 (其中 R22 为氢或低级烷基），R3 为具有 2 至 22 个碳原子的饱和或不饱和、直链或支链脂族基团、苯基-低级烷基、取代的苯基-低级烷基、取代或未取代的苯基-甲基羟乙基或 2-羟乙基。
• Pyrazolo [4,3-d] pyrimidine derivative, process for its production, and antihyperlipidemic or antiatheroschlerotic agent containing it
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0210653A2

  公开（公告）日：1987-02-04

  A pyrazolo[4,3-d]pyrimidine derivative having the formula: wherein R' is lower alkyl or phenyl which is unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; R2 is a saturated or unsaturated, straight chain or branched aliphatic group having from 2 to 22 carbon atoms or phenyl-lower alkyl with the phenyl group unsubstituted or substituted by lower alkyl, lower alkoxy or halogen; and A is an alkylene group having from 1 to 3 carbon atoms which is unsubstituted or substituted by methyl, or a pharmaceutically acceptable salt thereof

  一种吡唑并[4,3-d]嘧啶衍生物，其式如下 其中 R' 是低级烷基或未被低级烷基、低级烷氧基或卤素取代或取代的苯基；R2 是具有 2 至 22 个碳原子的饱和或不饱和、直链或支链脂肪族基团或苯基-低级烷基，其中苯基未被低级烷基、低级烷氧基或卤素取代或取代；以及 A 是具有 1 至 3 个碳原子的未被甲基取代或取代的亚烷基，或其药学上可接受的盐
• FUJIKAWA, YOSHIHIRO;SUZUKI, MIKIO;SAKASHITA, MITSUAKI;TSURUZOE, NOBUTOMO;+
  作者：FUJIKAWA, YOSHIHIRO、SUZUKI, MIKIO、SAKASHITA, MITSUAKI、TSURUZOE, NOBUTOMO、+

  DOI：——

  日期：——
• US4654348A
  申请人：——

  公开号：US4654348A

  公开（公告）日：1987-03-31
• US4746663A
  申请人：——

  公开号：US4746663A

  公开（公告）日：1988-05-24