3-(2-hydroxyethyl)-1-propylquinazoline-2,4(1H,3H)-dione | 1242057-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 3-(2-hydroxyethyl)-1-propylquinazoline-2,4(1H,3H)-dione
• 英文别名: 3-(2-hydroxyethyl)-1-propylquinazoline-2,4-dione
• CAS: 1242057-13-1
• 化学式: C₁₃H₁₆N₂O₃
• mdl: MFCD20504169
• 分子量: 248.282
• InChiKey: PUHQQKGIXAJYCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-hydroxyethyl)-1-propylquinazoline-2,4(1H,3H)-dione 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 以95%的产率得到3-(2-Chloroethyl)-1-propylquinazoline-2,4-dione
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 173*. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents

  摘要：

  Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

  DOI：

  10.1007/s10593-010-0475-4
• 作为产物：
  描述：

  3-(2-羟基乙基)-2,4-(1h,3h)-喹唑啉二酮 、 alkaline earth salt of/the/ methylsulfuric acid 在 potassium carbonate 作用下， 以 二甲基亚砜 为溶剂， 反应 4.0h， 以83%的产率得到3-(2-hydroxyethyl)-1-propylquinazoline-2,4(1H,3H)-dione
  参考文献：
  名称：

  4-Hydroxy-2-quinolones 173*. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents

  摘要：

  Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.

  DOI：

  10.1007/s10593-010-0475-4

文献信息

• 4-Hydroxy-2-quinolones 173*. 1-R-3-(2-diethylamino- ethyl)-1H-quinazoline- 2,4-dione hydrochlorides as potential local anesthetic agents
  作者：I. V. Ukrainets、V. V. Kravtsova、A. A. Tkach、V. I. Mamchur、E. Yu. Kovalenko

  DOI：10.1007/s10593-010-0475-4

  日期：2010.5

  Different variants of the preparation and procedures in the synthesis of a series of 1-R-3-(2-dialkylaminoethyl)-1H-quinazoline-2,4-dione hydrochlorides having a structural similarity to the 4-hydroxy-2-quinolinone anesthetic chinoxicaine are discussed. A comparative analysis of the biological properties of the synthesized compounds and the known local anesthetics chinoxicaine and lidocaine is reported.