3-(4-methoxyphenyl)-2-(4-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine | 1207178-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: 3-(4-methoxyphenyl)-2-(4-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine
• 英文别名: 3-(4-Methoxyphenyl)-2-(4-nitrophenyl)-2,4-dihydro-1,3-benzoxazine
• CAS: 1207178-64-0
• 化学式: C₂₁H₁₈N₂O₄
• 分子量: 362.385
• InChiKey: LPXKJTDGMVTOQU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  67.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  水杨醛 在 sodium tetrahydroborate 、 四氯化锡 作用下， 以 甲醇 、 乙醇 、 氯仿 、 环己烷 为溶剂， 反应 5.0h， 生成 3-(4-methoxyphenyl)-2-(4-nitrophenyl)-3,4-dihydro-2H-benzo[e][1,3]oxazine
  参考文献：
  名称：

  SnCl₄-Catalyzed Aza-Acetalization of Aromatic Aldehydes: Synthesis of Aryl Substituted 3,4-Dihydro-2H-1,3-benzoxazines

  摘要：

  Stannic tetrachloride was an efficient Lewis acid catalyst for the aza-acetalization of aromatic aldehydes with o-arylaminomethyl phenols, and a series of novel aryl substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in good yields under mild conditions. SnCl4 was a more efficient catalyst for the reaction than p-toluenesulfonic acid, sulfuric acid, and aluminium chloride.

  DOI：

  10.1080/00397911.2010.540691

文献信息

• SnCl₄-Catalyzed Aza-Acetalization of Aromatic Aldehydes: Synthesis of Aryl Substituted 3,4-Dihydro-<i>2H</i>-1,3-benzoxazines
  作者：Zilong Tang、Weiwen Chen、Zhonghua Zhu、Hanwen Liu

  DOI：10.1080/00397911.2010.540691

  日期：2012.5.1

  Stannic tetrachloride was an efficient Lewis acid catalyst for the aza-acetalization of aromatic aldehydes with o-arylaminomethyl phenols, and a series of novel aryl substituted 3,4-dihydro-2H-1,3-benzoxazines were prepared in good yields under mild conditions. SnCl4 was a more efficient catalyst for the reaction than p-toluenesulfonic acid, sulfuric acid, and aluminium chloride.