2-[2-(9H-fluoren-9-ylmethoxycarbonyl)hydrazinyl]acetic acid | 808733-35-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-[2-(9H-fluoren-9-ylmethoxycarbonyl)hydrazinyl]acetic acid
• CAS: 808733-35-9
• 化学式: C₁₇H₁₆N₂O₄
• 分子量: 312.325
• InChiKey: PFLATEVPHXRIIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  烯丙基2-溴乙酸乙酯 、 2-[2-(9H-fluoren-9-ylmethoxycarbonyl)hydrazinyl]acetic acid 在 N,N-二异丙基乙胺 作用下， 反应 2.0h， 以19%的产率得到Fmoc-aza-β³-Asp-OAllyl
  参考文献：
  名称：

  Fmoc-aza-β3-Lys-OAllyl and Fmoc-aza-β3-Asp-OAllyl for on-resin head-to-tail cyclization of aza-β3-peptides

  摘要：

  A rapid and efficient Fmoc/t-Bu solid-phase peptide synthesis (SPPS) of cyclic aza-beta(3)-peptide analogs by allyl strategy is described. Our synthetic approach includes the synthesis of two new aza-beta(3)-amino acids, Fmoc-aza-beta(3)-Lys-OAllyl and Fmoc-aza-beta(3)-Asp-OAllyl, then the resin attachment of the first aza-beta(3)-amino acid via its side chain, successful use of combination of three orthogonal removable protecting groups, stepwise solid-phase synthesis of linear peptide analog, and on-resin head-to-tail cyclization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.11.113

文献信息

• Peptide analogues comprising at least one type of aminoacylaza-$g(b)<sp>3</sp>and the use thereof, in particular for therapy
  申请人：Baudy Floc'h Michele

  公开号：US20110044974A1

  公开（公告）日：2011-02-24

  The object of the present invention is analogues of peptides or parent proteins, these peptide analogues, comprising at least one aza-β 3 aminoacyl residue, and also their uses in pharmaceutical compositions or for the diagnosis of pathologies wherein the aforesaid peptides or parent proteins are involved.

  本发明的对象是肽或母体蛋白的类似物，这些肽类似物包括至少一个aza-β3氨基酰残基，并且它们在药物组合物中的用途或用于诊断涉及上述肽或母体蛋白的病理的用途。
• Products comprising a support to which nucleic acids are fixed and their use as dna chips
  申请人：——

  公开号：US20030162185A1

  公开（公告）日：2003-08-28

  The invention concerns products comprising a support whereon are fixed nucleic acids and their preparation method and use as DNA support. The invention also concerns functionalised supports, oligonucleotides and DNA's modified in position 5′ by a group selected in the group consisting of tartaric acid, serine, threonine, their derivatives and the &agr;-oxoaldehyde group, and the methods for preparing them. The invention further concerns a method for fixing a nucleic acid on a support.

  本发明涉及由固定核酸的支持物组成的产品及其制备方法和作为 DNA 支持物的用途。本发明还涉及在 5′位被酒石酸、丝氨酸、苏氨酸、它们的衍生物和&agr;-氧代甲醛基团组成的基团修饰的功能化支持物、寡核苷酸和 DNA，以及制备它们的方法。本发明还涉及一种将核酸固定在支持物上的方法。
• NOVEL COMPOUNDS OF REVERSE TURN MIMETICS AND THE USE THEREOF
  申请人：Choongwae Pharma Corporation

  公开号：EP2212328B1

  公开（公告）日：2017-01-25
• US9017673B2
  申请人：——

  公开号：US9017673B2

  公开（公告）日：2015-04-28
• Fmoc-aza-β3-Lys-OAllyl and Fmoc-aza-β3-Asp-OAllyl for on-resin head-to-tail cyclization of aza-β3-peptides
  作者：Shoukri Abbour、Michèle Baudy-Floc’h

  DOI：10.1016/j.tetlet.2012.11.113

  日期：2013.2

  A rapid and efficient Fmoc/t-Bu solid-phase peptide synthesis (SPPS) of cyclic aza-beta(3)-peptide analogs by allyl strategy is described. Our synthetic approach includes the synthesis of two new aza-beta(3)-amino acids, Fmoc-aza-beta(3)-Lys-OAllyl and Fmoc-aza-beta(3)-Asp-OAllyl, then the resin attachment of the first aza-beta(3)-amino acid via its side chain, successful use of combination of three orthogonal removable protecting groups, stepwise solid-phase synthesis of linear peptide analog, and on-resin head-to-tail cyclization. (C) 2012 Elsevier Ltd. All rights reserved.