cyclohexanecarboxylic acid (3-hydroxymethyl-4-methylpyridin-2-ylmethyl)-amide | 1174132-94-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cyclohexanecarboxylic acid (3-hydroxymethyl-4-methylpyridin-2-ylmethyl)-amide
• CAS: 1174132-94-5
• 化学式: C₁₅H₂₂N₂O₂
• 分子量: 262.352
• InChiKey: WIMYSROHKMPNKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.08
• 重原子数：
  19.0
• 可旋转键数：
  4.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  62.22
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  cyclohexanecarboxylic acid (3-hydroxymethyl-4-methylpyridin-2-ylmethyl)-amide 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-[[3-(chloromethyl)-4-methylpyridin-2-yl]methyl]cyclohexanecarboxamide
  参考文献：
  名称：

  Novel Small Molecule Bradykinin B₂ Receptor Antagonists

  摘要：

  Blockade of the bradykinin B, receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B, receptor antagonists with a molecular weight of approximately 500 g/mol. First, known quinoline-based B-2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the minimum pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B-2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B-2 receptor, Optimization of the microsomal stability and cytochrome P450 inhibition eventually led to the discovery of the highly potent and orally available B-2 receptor antagonist 52e (JSM 10292), which showed the best overall properties.

  DOI：

  10.1021/jm9002445
• 作为产物：
  描述：

  (2-氨基甲基-4-甲基-吡啶-3-基)-甲醇 、 环己甲酰氯 在 sodium carbonate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 2.5h， 以74%的产率得到cyclohexanecarboxylic acid (3-hydroxymethyl-4-methylpyridin-2-ylmethyl)-amide
  参考文献：
  名称：

  Novel Small Molecule Bradykinin B₂ Receptor Antagonists

  摘要：

  Blockade of the bradykinin B, receptor provides therapeutic benefit in hereditary angioedema (HAE) and potentially in many other diseases. Herein, we describe the development of highly potent B, receptor antagonists with a molecular weight of approximately 500 g/mol. First, known quinoline-based B-2 receptor antagonists were stripped down to their shared core motif 53, which turned out to be the minimum pharmacophore. Targeted modifications of 53 resulted in the highly water-soluble lead compound 8a. Extensive exploration of its structure-activity relationship resulted in a series of highly potent B-2 receptor antagonists, featuring a hydrogen bond accepting functionality, which presumably interacts with the side chain of Asn-107 of the B-2 receptor, Optimization of the microsomal stability and cytochrome P450 inhibition eventually led to the discovery of the highly potent and orally available B-2 receptor antagonist 52e (JSM 10292), which showed the best overall properties.

  DOI：

  10.1021/jm9002445