N-Cyclohexyl-4-methyl-2-pyrrolidone | 96240-05-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-Cyclohexyl-4-methyl-2-pyrrolidone
• 英文别名: 1-cyclohexyl-4-methyl-pyrrolidin-2-one；1-cyclohexyl-4-methylpyrrolidin-2-one
• CAS: 96240-05-0
• 化学式: C₁₁H₁₉NO
• 分子量: 181.278
• InChiKey: QQUJSYBYZSOURX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-Cyclohexyl-4-methyl-2-pyrrolidone 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 15.0h， 以82%的产率得到N-Cyclohexyl-3-methyl-1-pyrrolidine
  参考文献：
  名称：

  Lin, Tay-yean; Kingsbury, Charles A.; Cromwell, Norman H., Journal of Heterocyclic Chemistry, 1984, vol. 21, p. 1871 - 1875

  摘要：

  DOI：
• 作为产物：
  描述：

  Methyl 4-Cyclohexylamino-3-methylbutanoate Hydrochloride 以76%的产率得到
  参考文献：
  名称：

  LIN, TAY-YEAN;KINGSBURY, CH. A.;CROMWELL, N. H., J. HETEROCYCL. CHEM., 1984, 21, N 6, 1871-1875

  摘要：

  DOI：

文献信息

• Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1
  申请人：Aicher Thomas Daniel

  公开号：US20080275043A1

  公开（公告）日：2008-11-06

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Fomula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明公开了具有11beta-HSD type 1拮抗活性的化合物的公式I：（I），以及制备这种化合物的方法。在另一实施例中，本发明公开了包含公式I化合物的制药组合物，以及将公式I和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，综合征X和与高血糖有关的其他疾病的用途。
• CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
  申请人：AICHER Thomas Daniel

  公开号：US20100184764A1

  公开（公告）日：2010-07-22

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明揭示了具有11beta-HSD type 1拮抗活性的I式化合物：（I），以及制备这种化合物的方法。在另一种实施方式中，本发明揭示了包括I式化合物的制药组合物，以及将I式和组合物用作药物治疗糖尿病，高血糖，肥胖症，高血压，高脂血症，X综合症和其他与高血糖有关的疾病的用途。
• Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
  申请人：Eli Lilly and Company

  公开号：US07713979B2

  公开（公告）日：2010-05-11

  The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.

  本发明公开了具有11beta-HSD类型1拮抗活性的I式化合物(I)，以及制备这些化合物的方法。在另一实施例中，本发明公开了包含I式化合物的药物组合物，以及将I式化合物和组合物用作药物治疗糖尿病、高血糖、肥胖症、高血压、高脂血症、X综合症以及与高血糖相关的其他病症的用途。
• WO2006/49952
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis of pyrrolidines and pyrrolidinones by the rhodium complex catalyzed cyclization of unsaturated amines
  作者：Jian Qiang Zhou、Howard Alper

  DOI：10.1021/jo00038a019

  日期：1992.6

  N-Allylic arylamines react with carbon monoxide, sodium borohydride, 2-propanol, and catalytic amounts of the zwitterionic complex eta-6-C6H6BPh3-Rh(COD)+ (1), to form pyrrolidines as the main products in most cases. Pyrrolidinones result from N-allylic alkylamines. An alternate route to the lactams from N-allylic alkylamines involves synthesis gas instead of CO/NaBH4, together with the dual catalytic system 1/[Ru(CO)3Cl2]2. Complementary to the N-allylic arylamine route to pyrrolidines with NaBH4 and 1 is the use of synthesis gas, 1, and 1,4-bis(diphenylphosphino)butane.