2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester | 71953-00-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester
• 英文别名: tert-butyl 2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoate
• CAS: 71953-00-9
• 化学式: C₂₂H₂₅NO₄
• 分子量: 367.445
• InChiKey: YCONQKUYCNMLCA-UHFFFAOYSA-N

物化性质

• 沸点：
  516.9±33.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid tert-butyl ester 在 ytterbium(III) triflate 作用下， 以 硝基甲烷 为溶剂， 反应 5.0h， 以97%的产率得到芴甲氧羰基-DL-丙氨酸
  参考文献：
  名称：

  Sridhar, P. Ramu; Sinha, Surajit; Chandrasekaran, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002, vol. 41, # 1, p. 157 - 160

  摘要：

  DOI：

文献信息

• Methods for the site-selective coupling of a first agent to a second agent
  申请人：UNIVERSITEIT GENT

  公开号：US11053279B2

  公开（公告）日：2021-07-06

  The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.

  本发明涉及一种将第一药剂与第二药剂进行位点选择性偶联的方法，包括以下步骤：将包含至少一个呋喃分子的第一药剂与活化信号接触，并与包含至少一个肼分子或至少一个羟胺分子的第二药剂接触，从而将所述呋喃分子活化为活化的呋喃分子；以及将所述活化的呋喃分子与肼分子或羟胺分子反应，从而将所述第一药剂与所述第二药剂进行位点选择性偶联。
• METHODS FOR THE SITE-SELECTIVE COUPLING OF A FIRST AGENT TO A SECOND AGENT
  申请人：UNIVERSITEIT GENT

  公开号：US20190002494A1

  公开（公告）日：2019-01-03

  The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.
• METHODS FOR COVALENTLY BINDING A CELL SURFACE PROTEIN AND A LIGAND
  申请人：UNIVERSITEIT GENT

  公开号：US20210018512A1

  公开（公告）日：2021-01-21

  The present invention relates to a method for covalently binding a cell surface protein and a ligand, the ligand being capable of specifically binding to the cell surface protein, the method consisting essentially of contacting the living cells expressing the cell surface protein with the ligand comprising at least one furan moiety, thereby covalently binding the cell surface protein and the ligand.
• US9708363B2
  申请人：——

  公开号：US9708363B2

  公开（公告）日：2017-07-18