bis(4-(dimethylamino)phenyl)chlorophosphine | 125518-41-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(4-(dimethylamino)phenyl)chlorophosphine
• 英文别名: 4-[chloro-[4-(dimethylamino)phenyl]phosphanyl]-N,N-dimethylaniline
• CAS: 125518-41-4
• 化学式: C₁₆H₂₀ClN₂P
• 分子量: 306.775
• InChiKey: VXENTRDSSSLHCS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-N,N-dimethyl-1-ferrocenylethylamine 、 bis(4-(dimethylamino)phenyl)chlorophosphine 在 仲丁基锂 作用下， 以 乙醚 、 环己烷 为溶剂， 以27%的产率得到dimethyl((R)-1-[(S)-2-(bis(4-(dimethylamino)phenyl)phosphino)ferrocenyl]ethyl)amine
  参考文献：
  名称：

  含吡唑的二茂铁基配体的合成和结构不对称催化

  摘要：

  A series of new chiral ferrocenyl chelating ligands containing a tertiary phosphine and a pyrazole moiety (3) have been obtained in moderate to good yields from the reaction of the corresponding phosphinoferrocenyl amine derivatives 1a-k with the 1H-pyrazoles 2a-w in acetic acid at temperatures between 70 and 90 degrees C. For unsymmetrically substituted pyrazoles a remarkable site selectivity is observed, leading in most cases to only one regioisomer. Six compounds have been characterized by X-ray diffraction and were found to display very similar conformational features.

  DOI：

  10.1021/om00011a069

文献信息

• Tolmachev, A. A.; Kostyuk, A. N.; Kozlov, E. S., Journal of general chemistry of the USSR, 1990, vol. 60, # 8.1, p. 1563 - 1571
  作者：Tolmachev, A. A.、Kostyuk, A. N.、Kozlov, E. S.、Pinchuk, A. M.

  DOI：——

  日期：——
• TOLMACHEV, A. A.;KOSTYUK, A. N.;KOZLOV, EH. S.;PINCHUK, A. M., ZH. OBSHCH. XIMII, 60,(1990) N, S. 1752-1761
  作者：TOLMACHEV, A. A.、KOSTYUK, A. N.、KOZLOV, EH. S.、PINCHUK, A. M.

  DOI：——

  日期：——
• US6084133A
  申请人：——

  公开号：US6084133A

  公开（公告）日：2000-07-04
• Synthesis and Structure of Pyrazole-Containing Ferrocenyl Ligands for Asymmetric Catalysis
  作者：Urs Burckhardt、Lukas Hintermann、Anita Schnyder、Antonio Togni

  DOI：10.1021/om00011a069

  日期：1995.11

  A series of new chiral ferrocenyl chelating ligands containing a tertiary phosphine and a pyrazole moiety (3) have been obtained in moderate to good yields from the reaction of the corresponding phosphinoferrocenyl amine derivatives 1a-k with the 1H-pyrazoles 2a-w in acetic acid at temperatures between 70 and 90 degrees C. For unsymmetrically substituted pyrazoles a remarkable site selectivity is observed, leading in most cases to only one regioisomer. Six compounds have been characterized by X-ray diffraction and were found to display very similar conformational features.